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Calcium-sensing receptor polymorphisms increase the risk of osteoporosis in ageing males.

作者信息

Di Nisio Andrea, Rocca Maria Santa, Ghezzi Marco, Ponce Maurizio De Rocco, Taglianetti Stefano, Plebani Mario, Ferlin Alberto, Foresta Carlo

机构信息

Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.

Department of Medicine, Laboratory Medicine, University of Padova, Padova, Italy.

出版信息

Endocrine. 2018 Aug;61(2):349-352. doi: 10.1007/s12020-017-1429-8. Epub 2017 Oct 10.

DOI:10.1007/s12020-017-1429-8
PMID:29019102
Abstract
摘要

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本文引用的文献

1
The calcium-sensing receptor in bone--mechanistic and therapeutic insights.骨钙敏感受体的作用机制及治疗学研究进展
Nat Rev Endocrinol. 2015 May;11(5):298-307. doi: 10.1038/nrendo.2015.30. Epub 2015 Mar 10.
2
Factors associated with vertebral fracture risk in patients with primary hyperparathyroidism.与原发性甲状旁腺功能亢进症患者椎体骨折风险相关的因素。
Eur J Endocrinol. 2014 Sep;171(3):399-406. doi: 10.1530/EJE-14-0343. Epub 2014 Jun 25.
3
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
Int J Mol Sci. 2020 Oct 31;21(21):8183. doi: 10.3390/ijms21218183.
4
The role of GPCRs in bone diseases and dysfunctions.G蛋白偶联受体在骨骼疾病及功能障碍中的作用。
Bone Res. 2019 Jul 8;7:19. doi: 10.1038/s41413-019-0059-6. eCollection 2019.
全基因组关联研究的荟萃分析确定了血清钙浓度的 6 个新位点。
PLoS Genet. 2013;9(9):e1003796. doi: 10.1371/journal.pgen.1003796. Epub 2013 Sep 19.
4
Clinical phenotypes of Chinese primary hyperparathyroidism patients are associated with the calcium-sensing receptor gene R990G polymorphism.中国原发性甲状旁腺功能亢进症患者的临床表型与钙敏感受体基因 R990G 多态性相关。
Eur J Endocrinol. 2013 Oct 1;169(5):629-38. doi: 10.1530/EJE-13-0441. Print 2013 Nov.
5
Osteoporosis in men.男性骨质疏松症。
Endocr Pract. 2013 Sep-Oct;19(5):834-8. doi: 10.4158/EP13114.RA.
6
genepop'007: a complete re-implementation of the genepop software for Windows and Linux.genepop'007：一个用于 Windows 和 Linux 的 genepop 软件的完全重新实现。
Mol Ecol Resour. 2008 Jan;8(1):103-6. doi: 10.1111/j.1471-8286.2007.01931.x.
7
Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis.骨密度与睾丸功能衰竭：维生素 D25-羟化酶在人睾丸中的作用证据。
J Clin Endocrinol Metab. 2011 Apr;96(4):E646-52. doi: 10.1210/jc.2010-1628. Epub 2011 Jan 26.
8
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.钙敏感受体基因中的常见变异与总血清钙水平相关。
Hum Mol Genet. 2010 Nov 1;19(21):4296-303. doi: 10.1093/hmg/ddq342. Epub 2010 Aug 12.
9
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J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59. doi: 10.1210/jc.2009-2354.
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R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria.钙敏感受体的R990G多态性确实会产生功能增益并易患原发性高钙尿症。
Kidney Int. 2007 Jun;71(11):1155-62. doi: 10.1038/sj.ki.5002156. Epub 2007 Feb 28.