Wettstein J G
Department of Psychiatry, Harvard Medical School, Boston, MA 02115.
Eur J Pharmacol. 1988 Jul 7;151(2):341-4. doi: 10.1016/0014-2999(88)90821-7.
The effects of buspirone were studied in squirrel monkeys trained to lever-press under a fixed-interval schedule involving suppressed responding. Buspirone (0.01-0.1 mg/kg) generally did not increase rates of suppressed responding. Buspirone (0.01-0.1 mg/kg) generally did not increase rates of suppressed responding; 0.3 mg/kg of buspirone decreased rate. In comparison, diazepam (0.1-1.0 mg/kg) and CL 218872 (0.3-3.0 mg/kg) increased responding. Additionally, the effects of buspirone (0.01-0.3 mg/kg) were unchanged over a 12-day period of daily administration. The results show that buspirone has effects on schedule-controlled behavior of squirrel monkeys that differ from those of typical anxiolytic drugs.
在按固定间隔时间表训练进行杠杆按压且存在反应抑制的松鼠猴中研究了丁螺环酮的作用。丁螺环酮（0.01 - 0.1毫克/千克）通常不会提高反应抑制率。丁螺环酮（0.01 - 0.1毫克/千克）通常不会提高反应抑制率；0.3毫克/千克的丁螺环酮会降低反应率。相比之下，地西泮（0.1 - 1.0毫克/千克）和CL 218872（0.3 - 3.0毫克/千克）会提高反应率。此外，在为期12天的每日给药期间，丁螺环酮（0.01 - 0.3毫克/千克）的作用没有变化。结果表明，丁螺环酮对松鼠猴的时间表控制行为的影响与典型抗焦虑药物不同。
