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肺炎克雷伯菌对仓鼠纤毛气管细胞的体外黏附是由1型菌毛介导的证据。

Evidence that in vitro adherence of Klebsiella pneumoniae to ciliated hamster tracheal cells is mediated by type 1 fimbriae.

作者信息

Fader R C, Gondesen K, Tolley B, Ritchie D G, Moller P

机构信息

Shriners Burns Institute, University of Texas Medical Branch, Galveston 77550.

出版信息

Infect Immun. 1988 Nov;56(11):3011-3. doi: 10.1128/iai.56.11.3011-3013.1988.

DOI:10.1128/iai.56.11.3011-3013.1988
PMID:2902014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259688/
Abstract

Clinical isolates of fimbriated and nonfimbriated Klebsiella pneumoniae were examined for the ability to adhere to hamster tracheal cells cultured in vitro. Fimbriated-phase K. pneumoniae adhered preferentially to ciliated cells, whereas nonfimbriated-phase organisms were not adherent. The adherence was inhibited by D-mannose but not D-glucose, suggesting that type 1 fimbriae serve as the adhesin in the attachment process.

摘要

对有菌毛和无菌毛的肺炎克雷伯菌临床分离株进行检测，以观察其对体外培养的仓鼠气管细胞的黏附能力。菌毛相肺炎克雷伯菌优先黏附于纤毛细胞，而无菌毛相细菌则不具有黏附性。这种黏附作用被D-甘露糖抑制，但不被D-葡萄糖抑制，这表明1型菌毛在黏附过程中作为黏附素发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/140c/259688/9b612bf35118/iai00083-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/140c/259688/ef15c3760a91/iai00083-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/140c/259688/9b612bf35118/iai00083-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/140c/259688/ef15c3760a91/iai00083-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/140c/259688/9b612bf35118/iai00083-0254-b.jpg

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