菌毛在铜绿假单胞菌黏附于受损气管上皮中的作用。
Role of pili in the adherence of Pseudomonas aeruginosa to injured tracheal epithelium.
作者信息
Ramphal R, Sadoff J C, Pyle M, Silipigni J D
出版信息
Infect Immun. 1984 Apr;44(1):38-40. doi: 10.1128/iai.44.1.38-40.1984.
Abstract
Pili have been demonstrated to be the adhesins of nonmucoid Pseudomonas aeruginosa for buccal cells. In this study, we examined their role in the adherence of both mucoid and nonmucoid strains to injured tracheal cells. Pili incubated with tracheal cells inhibited the adherence of a nonmucoid strain in a dose-dependent manner. Both homologous and heterologous pili inhibited this nonmucoid strain. Antibody against pili from the nonmucoid strain inhibited adherence of the homologous but not a heterologous strain. Pili failed to inhibit two mucoid strains, but inhibited nonmucoid variants derived from mucoid strains. These studies suggest that pili mediate the adherence of nonmucoid strains to injured tracheal cells but that they are not the final mediators of adherence of mucoid strains. It is also inferred that there are differences in the receptor for mucoid and nonmucoid strains.
摘要
菌毛已被证明是非黏液型铜绿假单胞菌黏附颊细胞的黏附素。在本研究中，我们检测了它们在黏液型和非黏液型菌株黏附受损气管细胞中的作用。与气管细胞一起孵育的菌毛以剂量依赖的方式抑制非黏液型菌株的黏附。同源和异源菌毛均能抑制该非黏液型菌株。来自非黏液型菌株的菌毛抗体抑制同源菌株的黏附，但不抑制异源菌株的黏附。菌毛未能抑制两种黏液型菌株，但能抑制源自黏液型菌株的非黏液型变体。这些研究表明，菌毛介导非黏液型菌株黏附受损气管细胞，但它们不是黏液型菌株黏附的最终介质。还推断出黏液型和非黏液型菌株的受体存在差异。
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1
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Infect Immun. 1980 Dec;30(3):694-9. doi: 10.1128/iai.30.3.694-699.1980.
2
Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation.铜绿假单胞菌对因流感感染或气管插管而受损的气管细胞的黏附。
Infect Immun. 1980 Feb;27(2):614-9. doi: 10.1128/iai.27.2.614-619.1980.
3
Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium.黏液型和非黏液型铜绿假单胞菌对酸损伤气管上皮的黏附
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4
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5
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Crit Rev Microbiol. 1981;8(4):303-38. doi: 10.3109/10408418109085082.
6
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7
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8
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