Hewson Thomas, McKeever Tricia M, Gibson Jack E, Navaratnam Vidya, Hubbard Richard B, Hutchinson John P
Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.
Thorax. 2017 Oct 11. doi: 10.1136/thoraxjnl-2017-210177.
Little is known about when symptoms of idiopathic pulmonary fibrosis first develop. We identified incident cases of idiopathic pulmonary fibrosis-clinical syndrome (IPF-CS) from a UK primary care database and assessed the frequency of consultations for common symptoms in the 5 years prior to diagnosis. 1671 cases were identified with 5 years of data prior to diagnosis. Breathlessness was the most common symptom, followed by cough. Cases were significantly more likely than controls to experience these symptoms (p<0.001), even 4-5 years before diagnosis (OR for breathlessness for this period 2.79, 95% CI 2.13 to 3.65). This suggests that some patients with IPF may be symptomatic for more than 5 years before diagnosis.
关于特发性肺纤维化的症状何时首次出现，目前所知甚少。我们从英国初级医疗数据库中识别出特发性肺纤维化临床综合征（IPF-CS）的新发病例，并评估了诊断前5年常见症状的就诊频率。共识别出1671例有诊断前5年数据的病例。呼吸困难是最常见的症状，其次是咳嗽。与对照组相比，这些病例出现这些症状的可能性显著更高（p<0.001），甚至在诊断前4至5年也是如此（此期间呼吸困难的比值比为2.79，95%置信区间为2.13至3.65）。这表明一些特发性肺纤维化患者在诊断前可能出现症状超过5年。
