Kim Ji Hye, Yi Young-Su, Kim Mi-Yeon, Cho Jae Youl
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Department of Pharmaceutical Engineering, Cheongju University, Cheongju, Republic of Korea.
J Ginseng Res. 2017 Oct;41(4):435-443. doi: 10.1016/j.jgr.2016.08.004. Epub 2016 Aug 18.
is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB and activator protein-1. This review discusses recent studies regarding molecular mechanisms by which ginsenosides play critical roles in inflammatory responses and diseases, and provides evidence showing their potential to prevent and treat inflammatory diseases.
它是亚洲和西方国家最普遍使用的草药之一。人参的大多数生物活性都源自其主要成分人参皂苷。有趣的是，许多研究报告称，人参皂苷及其代谢产物/衍生物——包括人参皂苷（G）-Rb1、化合物K、G-Rb2、G-Rd、G-Re、G-Rg1、G-Rg3、G-Rg5、G-Rh1、G-Rh2和G-Rp1——通过抑制促炎细胞因子的产生和调节炎症信号通路（如核因子-κB和激活蛋白-1）的活性，在炎症反应中发挥抗炎作用。本综述讨论了关于人参皂苷在炎症反应和疾病中发挥关键作用的分子机制的最新研究，并提供证据表明其具有预防和治疗炎症性疾病的潜力。
