Buimovici-Klein E, Lange M, Ong K R, Grieco M H, Cooper L Z
Department of Pediatrics, St. Luke's-Roosevelt Hospital Center, New York, NY 10019.
J Med Virol. 1988 Aug;25(4):371-85. doi: 10.1002/jmv.1890250402.
Virus shedding was detected in 77% of homosexual subjects and in only 6% of heterosexual controls. The overall virus isolation rate in homosexual subjects was not significantly different among HIV-seropositive (79%) and HIV-seronegative (74%) individuals. In about 20% of homosexual subjects, virus shedding from multiple sites was observed. The most frequently isolated virus was cytomegalovirus (CMV) (41%), followed by enteroviruses (23%), herpes simplex virus (HSV) (7%), and adenoviruses (6%). In the control group, about 50% of subjects were seronegative for HSV-1 and 2, and about 70% were negative for CMV and Epstein-Barr virus (EBV). Only 2% of homosexuals were seronegative for CMV, about 5% for HSV-1 and 2, and about 20% for EBV. No differences were found in antibody levels against varicella-zoster virus (VZV) among the control and homosexual groups. The proportion of seronegatives for Coxsackie and hepatitis viruses was significantly higher in control than in homosexual subjects. However, no differences in the proportion of seronegatives for measles, mumps, and rubella were observed. No HIV-antibody-negative individual was detected with an OKT4/OKT8 ratio of less than 0.75. On the other hand, only HIV-positive subjects, with a ratio of less than 0.75, had high serum IFN alpha titers. The results suggest that the high rate of virus shedding among HIV-negative homosexual subjects might be a factor in the development of AIDS in this high-risk population.
在77%的同性恋受试者中检测到病毒脱落，而在异性恋对照者中仅为6%。同性恋受试者中，HIV血清阳性个体（79%）和HIV血清阴性个体（74%）的总体病毒分离率无显著差异。在约20%的同性恋受试者中，观察到多个部位有病毒脱落。最常分离出的病毒是巨细胞病毒（CMV）（41%），其次是肠道病毒（23%）、单纯疱疹病毒（HSV）（7%）和腺病毒（6%）。在对照组中，约50%的受试者HSV-1和2血清学阴性，约70%的受试者CMV和EB病毒（EBV）阴性。仅2%的同性恋者CMV血清学阴性，约5%的人HSV-1和2阴性，约20%的人EBV阴性。对照组和同性恋组之间针对水痘-带状疱疹病毒（VZV）的抗体水平无差异。柯萨奇病毒和肝炎病毒血清学阴性的比例在对照组中显著高于同性恋受试者。然而，麻疹、腮腺炎和风疹血清学阴性的比例未观察到差异。未检测到OKT4/OKT8比值小于0.75的HIV抗体阴性个体。另一方面，只有比值小于0.75的HIV阳性受试者血清干扰素α滴度高。结果表明，HIV阴性同性恋受试者中病毒脱落率高可能是该高危人群发生艾滋病的一个因素。
