Department of Neurology, Zhejiang Hospital, 12 Lingyin Road, Hangzhou, China.
Aging Clin Exp Res. 2018 Jul;30(7):775-781. doi: 10.1007/s40520-017-0843-3. Epub 2017 Oct 11.
Clock-drawing test (CDT) is widely used but lack of a suitable scoring method.
To compare the validity of six common CDT scoring methods and to find out the best one.
The drawing CDT was administered in a Chinese nursing-home inhabitants living on the mainland including 110 dementia, 118 MCI (mild cognitive impairment), and 133 random normal. We calculated the sensitivity and specificity of six scoring methods and applied the receiver-operating characteristic (ROC) curve statistic, including determining the area under the curve (AUC).
(1) All six CDT scoring methods had a value of sensitivity higher than 80% and a specificity of 60% except Jouk and Tuokko. Freund got the highest sensitivity (92.73%) of that five for the testing of dementia and high sensitivity (82.20%) for MCI with an acceptable specificity (70.68%). (2) The AUC (area under the ROC curve) of all six CDT methods was over 0.8 for dementia, and for MCI, only Jouk and Tuokko were lower than 0.8. Mendez had the largest AUC of 0.872 for MCI, which closely followed by Freund with 0.859. (3) Freund predicted dementia best but had no significant difference (p > 0.05); it only had significant difference with Jouk and Tuokko (p < 0.001) and the method in MoCA (p < 0.05) for both MCI and cognitive impairment.
Our study suggests that Freund scoring method could be the best one among the six evaluated scoring methods within our setting.
画钟测验(CDT)被广泛应用,但缺乏合适的评分方法。
比较六种常见 CDT 评分方法的有效性,找出最佳方法。
在中国大陆的一家养老院中对 110 名痴呆症患者、118 名轻度认知障碍(MCI)患者和 133 名随机正常老年人进行了 CDT 测试。我们计算了六种评分方法的敏感性和特异性,并应用了受试者工作特征(ROC)曲线统计,包括确定曲线下面积(AUC)。
(1)除了 Jouk 和 Tuokko 评分法外,所有六种 CDT 评分方法的敏感性均高于 80%,特异性均为 60%。Freund 评分法对痴呆症的敏感性最高(92.73%),对 MCI 的敏感性也较高(82.20%),特异性也可接受(70.68%)。(2)六种 CDT 方法的 AUC(ROC 曲线下面积)均大于 0.8,对于 MCI,只有 Jouk 和 Tuokko 评分法的 AUC 低于 0.8。Mendez 评分法对 MCI 的 AUC 最大,为 0.872,紧随其后的是 Freund 评分法,为 0.859。(3)Freund 评分法对痴呆症的预测最佳,但与其他评分法之间无显著差异(p>0.05);仅与 Jouk 和 Tuokko 评分法(p<0.001)和 MoCA 评分法(p<0.05)有显著差异。
在我们的研究中,Freund 评分法可能是这六种评分方法中最好的方法。