a Instituto Federal de Educação , Ciência e Tecnologia do Sul de Minas Gerais, Campus Pouso Alegre , Minas Gerais , Brazil.
b Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto , Universidade de São Paulo , Ribeirão Preto , Brazil.
Nat Prod Res. 2018 Dec;32(23):2865-2868. doi: 10.1080/14786419.2017.1385007. Epub 2017 Oct 12.
We investigate the chemical composition and the antileishmanial and cytotoxic activities of the essential oils extracted from the leaves of (Nees) Mez (OD-EO) and (Vell) Rohwer (OO-EO). On the basis of GC-FID and GC-MS, α-eudesmol (20.9%), valencene (10.2%), δ-elemene (9.3%) and isospathulenol (7.3%) are the major constituents of OD-EO, whereas safrole (36.3%), γ-cadinene (6.6%), camphor (6.5%) and α-copaene (6.0%) are the main constituents of OO-EO. Both OD-EO and OO-EO display significant activity against the promastigote forms of , with IC values of 4.67 ± 0.95 and 11.67 ± 2.16 μg/mL, respectively. The 50% cytotoxic concentration (CC) of OD-EO and OO-EO to mouse peritoneal macrophages is 26.77 ± 4.06 and 49.52 ± 1.04 μg/mL, respectively. This is the first report on the chemical composition of the essential oil extracted from the leaves of . Our results suggest that OD-EO and OO-EO are a promising source of new antileishmanial agents.
我们研究了从（Nees）Mez（OD-EO）和（Vell）Rohwer（OO-EO）的叶子中提取的精油的化学成分以及抗利什曼原虫和细胞毒性活性。基于 GC-FID 和 GC-MS，α-依兰油醇（20.9％）、橙花叔醇（10.2％）、δ-榄香醇（9.3％）和异蒲桃醇（7.3％）是 OD-EO 的主要成分，而黄樟素（36.3％）、γ-杜松烯（6.6％）、樟脑（6.5％）和α-可巴烯（6.0％）是 OO-EO 的主要成分。OD-EO 和 OO-EO 均对前鞭毛体形式的具有显著的活性，IC 值分别为 4.67±0.95 和 11.67±2.16μg/mL。OD-EO 和 OO-EO 对小鼠腹腔巨噬细胞的 50％细胞毒性浓度（CC）分别为 26.77±4.06 和 49.52±1.04μg/mL。这是首次报道从叶子中提取的精油的化学成分。我们的结果表明，OD-EO 和 OO-EO 是有前途的新型抗利什曼原虫药物的来源。
