Dutton E, Carmichael N, Michal U, Cripps P J, Boswood A
Cheshire Cardiology, Knutsford, Cheshire WA16 8NE, UK.
Carmichael Torrance Diagnostic Services, Garforth, West Yorkshire LS25 1NB, UK.
J Small Anim Pract. 2018 Mar;59(3):167-173. doi: 10.1111/jsap.12771. Epub 2017 Oct 11.
To determine if serum cardiac troponin I concentrations - measured with both a first-generation assay and a high-sensitivity assay - were greater in dogs with generalised seizures than in controls and to identify clinical variables associated with cardiac troponin I concentration.
Prospective study of 30 dogs with recent generalised seizures and 30 healthy controls. Serum cardiac troponin I concentration was measured using two commercially available assays, and the correlation of clinical factors with concentration was examined.
Serum concentrations of cardiac troponin I were higher in dogs that had recent seizures compared to controls when measured by both assays. The predictors most clearly associated with cardiac troponin I concentration were number of seizures and age. Both predictors were positively associated with increasing concentrations of troponin I.
Serum cardiac troponin I concentration was significantly elevated in dogs that had recent generalised seizures when compared to controls, and concentrations were higher in dogs that experienced more seizures. This association may indicate that generalised seizures are associated with damage to the myocardium.
确定使用第一代检测法和高敏检测法测得的血清心肌肌钙蛋白I浓度在全身性癫痫发作的犬中是否高于对照组，并确定与心肌肌钙蛋白I浓度相关的临床变量。
对30只近期发生全身性癫痫发作的犬和30只健康对照犬进行前瞻性研究。使用两种市售检测法测量血清心肌肌钙蛋白I浓度，并检查临床因素与浓度的相关性。
通过两种检测法测量，近期发生癫痫发作的犬的血清心肌肌钙蛋白I浓度均高于对照组。与心肌肌钙蛋白I浓度最明显相关的预测因素是癫痫发作次数和年龄。这两个预测因素均与肌钙蛋白I浓度升高呈正相关。
与对照组相比，近期发生全身性癫痫发作的犬的血清心肌肌钙蛋白I浓度显著升高，发作次数更多的犬的浓度更高。这种关联可能表明全身性癫痫发作与心肌损伤有关。
