Ermert Johannes
Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, Jülich, Germany.
J Labelled Comp Radiopharm. 2018 Mar;61(3):179-195. doi: 10.1002/jlcr.3574. Epub 2017 Dec 22.
The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with positron-emitting radionuclides of groups 15 (pnicogens) and 16 (chalcogens) of the periodic table of elements. The positron emitters of the endogenous occurring elements nitrogen, phosphorus, oxygen, and sulphur are characterized by very short half-lives compared with the most commonly used PET radionuclides carbon-11 or fluorine-18. Therefore, the potential of their synthesis and possible applications in PET is challenging and limited. On the other hand, the nonstandard positron emitters arsenic-72, arsenic-74, and selenium-73 have half-lives in the range of hours to days and, thus, are of interest for PET studies of processes with long biological half-lives, but novel methods have to be developed for their application, especially in the no-carrier-added state. This review summarizes recent research concerning the positron emitters of pnicogens and chalcogens for radiolabelling applications.
正电子发射断层扫描（PET）在临床诊断中的重要性日益增加，这促使人们开发了多种用元素周期表第15族（氮族元素）和第16族（氧族元素）的正电子发射放射性核素标记的放射性示踪剂。与最常用的PET放射性核素碳-11或氟-18相比，内源性元素氮、磷、氧和硫的正电子发射体的半衰期非常短。因此，它们的合成潜力以及在PET中的可能应用具有挑战性且受到限制。另一方面，非标准正电子发射体砷-72、砷-74和硒-73的半衰期在数小时至数天的范围内，因此对于具有长生物半衰期的过程的PET研究具有吸引力，但必须开发新方法来应用它们，特别是在无载体添加状态下。本综述总结了有关用于放射性标记应用的氮族和氧族元素正电子发射体的最新研究。
