Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064, P. R. China.
Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15416-15420. doi: 10.1002/anie.201707862. Epub 2017 Oct 26.
The first thiocarboxylation of styrenes and acrylates with CO was realized by using visible light as a driving force and catalytic iron salts as promoters. A variety of important β-thioacids were obtained in high yields. This multicomponent reaction proceeds in an atom- and redox-economical manner with broad substrate scope under mild reaction conditions. Notably, high regio-, chemo-, and diasteroselectivity are observed. Mechanistic studies indicate that a radical pathway can account for the unusual regioselectivity.
通过使用可见光作为驱动力，并使用催化铁盐作为促进剂，首次实现了苯乙烯和丙烯酸酯与 CO 的硫代甲酰化反应。以高产率得到了多种重要的β-硫代酸。该多组分反应在温和的反应条件下以原子和氧化还原经济的方式进行，具有广泛的底物范围。值得注意的是，观察到高区域选择性、化学选择性和非对映选择性。机理研究表明，自由基途径可以解释这种不寻常的区域选择性。
