Manucha Varsha, Sessums Mary T, Lewin Jack, Akhtar Israh
Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Diagn Cytopathol. 2018 Mar;46(3):267-270. doi: 10.1002/dc.23839. Epub 2017 Oct 12.
The MiT family translocation renal cell carcinomas (RCCs) are relatively rare in comparison to the conventional RCC. The cytologic features overlap with conventional clear cell RCC and papillary RCCs, thereby making the diagnosis extremely challenging. Here, we describe a case of TFE3 translocation associated RCC in a 58-year-old patient, with emphasis on cytomorphologic features and clues toward this diagnostic entity. Correlating the cytohistologic findings and review of touch imprints revealed that presence of hyaline nodules resembling leisegang rings and psammoma bodies in cytologic smears from kidney tumors serve as an important clue in raising a suspicion for the diagnosis of MiT family translocation RCCs.
与传统肾细胞癌（RCC）相比，MiT家族易位性肾细胞癌相对少见。其细胞学特征与传统透明细胞RCC和乳头状RCC重叠，因此诊断极具挑战性。在此，我们描述一例58岁患者的TFE3易位相关性RCC，重点关注细胞形态学特征及该诊断实体的线索。将细胞组织学结果与触摸印片回顾相关联发现，肾肿瘤细胞学涂片上存在类似蕾西格环和砂粒体的透明结节，这是怀疑诊断MiT家族易位性RCC的重要线索。
