Sinnaeve Justine, Mobley Bret C, Ihrie Rebecca A
Departments of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
Am J Pathol. 2018 Jan;188(1):29-38. doi: 10.1016/j.ajpath.2017.08.029. Epub 2017 Oct 10.
Increasing evidence indicates that the adult neurogenic niche of the ventricular-subventricular zone (V-SVZ), beyond serving as a potential site of origin, affects the outcome of malignant brain cancers. Glioma contact with this niche predicts worse prognosis, suggesting a supportive role for the V-SVZ environment in tumor initiation or progression. In this review, we describe unique components of the V-SVZ that may permit or promote tumor growth within the region. Cell-cell interactions, soluble factors, and extracellular matrix composition are discussed, and the role of the niche in future therapies is explored. The purpose of this review is to highlight niche intrinsic factors that may promote or support malignant cell growth and maintenance, and point out how we might leverage these features to improve patient outcome.
越来越多的证据表明，脑室下区（V-SVZ）的成体神经发生微环境不仅是潜在的起源部位，还会影响恶性脑癌的预后。胶质瘤与该微环境的接触预示着更差的预后，这表明V-SVZ环境在肿瘤起始或进展中起支持作用。在这篇综述中，我们描述了V-SVZ中可能允许或促进该区域肿瘤生长的独特成分。讨论了细胞间相互作用、可溶性因子和细胞外基质组成，并探讨了该微环境在未来治疗中的作用。这篇综述的目的是强调可能促进或支持恶性细胞生长和维持的微环境内在因素，并指出我们如何利用这些特征来改善患者预后。
