Song Ji-Yeon, Mun Sue-Jean, Sung Soon-Ki, Hwang Jae-Yeon, Baik Seung-Kug, Kim Jee Yeon, Cheon Chong-Kun, Kim Su-Young, Kim Yoo-Mi
Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
Departments of Otorhinolaryngology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):197-202. doi: 10.6065/apem.2017.22.3.197. Epub 2017 Sep 28.
Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain, short stature, headache, and hypertension. On magnetic resonance imaging (MRI), only a left pituitary microadenoma was found. After surgery, transient clinical improvement was observed but headache and hypertension were observed again after 3 months later. Follow-up MRI showed a newly developed right pituitary microadenoma 6 months after the surgery. The need for careful clinical and radiographic follow-up should be emphasized in the search for potential MPAs in patients with persistent Cushing disease.
儿童和青少年的库欣病，尤其是伴有多发性垂体腺瘤（MPA）的情况非常罕见。我们报告了一名患有MPA的17岁男孩。他出现了椎体压缩性骨折、体重增加、身材矮小、头痛和高血压。在磁共振成像（MRI）检查中，仅发现了一个左垂体微腺瘤。手术后，观察到短暂的临床改善，但3个月后又出现了头痛和高血压。术后6个月的随访MRI显示出现了一个新的右垂体微腺瘤。在对患有持续性库欣病的患者寻找潜在MPA时，应强调仔细的临床和影像学随访的必要性。
