Kuroda Naoto, Yorita Kenji
Pol J Pathol. 2017;68(2):102-108. doi: 10.5114/pjp.2017.69685.
Recently, colon cancer with micropapillary pattern (MPP) has been identified. MPP is defined as tight tufts surrounded by cleft-like space and lacking true fibrovascular cores and showing reverse polarity. In this article, we studied nine cases of colon cancer with MPP. MPP usually accounted for a minor component in total tumour volume, which ranged from 3 to 40% with a mean percentage of 19.2%. Associated histological subtype showed moderately differentiated tubular adenocarcinoma in all cases. The reverse polarity of villin (9/9, diffuse) in MPP component was superior to that of CA125 (5/9, focal) or CD10 (5/9, diffuse 2/9, focal 3/9). In clinicopathological indicators such as sex, tumour location, tumour depth, lymphovascular invasion, lymph node metastasis, or pathological stage and clinical behaviour, there was statistically no difference between the MPP group and the non-MPP group of the colon. In conclusion, colon cancer with MPP is characterised by frequent association with moderately differentiated tubular adenocarcinoma as a minor component. Villin immunohistochemistry is useful in the detection of reverse polarity of MPP of colon cancer.
最近，已发现具有微乳头模式（MPP）的结肠癌。MPP被定义为被裂隙样间隙包围、缺乏真正纤维血管核心且显示极性反转的紧密簇状结构。在本文中，我们研究了9例具有MPP的结肠癌。MPP在肿瘤总体积中通常占较小部分，范围为3%至40%，平均百分比为19.2%。所有病例中相关的组织学亚型均为中分化管状腺癌。MPP成分中绒毛蛋白的极性反转（9/9，弥漫性）优于CA125（5/9，局灶性）或CD10（5/9，弥漫性2/9，局灶性3/9）。在性别、肿瘤位置、肿瘤深度、淋巴管侵犯、淋巴结转移、病理分期或临床行为等临床病理指标方面，结肠癌的MPP组与非MPP组之间在统计学上无差异。总之，具有MPP的结肠癌的特征是常与中分化管状腺癌相关且为次要成分。绒毛蛋白免疫组化有助于检测结肠癌MPP的极性反转。
