化妆品中二乙醇胺及其盐类的安全性评估。

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.

作者信息

Fiume Monice M, Heldreth Bart, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Andersen F Alan

机构信息

1 Senior Director, Cosmetic Ingredient Review, Washington, DC, USA.

2 Executive Director, Cosmetic Ingredient Review, Washington, DC, USA.

出版信息

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):89S-110S. doi: 10.1177/1091581817707179.

DOI:10.1177/1091581817707179

PMID:29025348

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports. Since data were not available for each individual ingredient, and since the salts dissociate freely in water, the Panel extrapolated from previous reports to support safety. The Panel concluded that diethanolamine and its salts are safe for use when formulated to be nonirritating. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

摘要

化妆品成分审查（CIR）专家小组评估了化妆品中使用的二乙醇胺及其盐类的安全性。二乙醇胺用作pH调节剂；本次重新审查中包含的16种盐类据报道可作为表面活性剂、乳化剂、增稠剂、头发或皮肤调理剂、泡沫促进剂或抗静电剂。该小组审查了现有的动物和临床数据，以及之前CIR报告中的信息。由于并非每种单独成分都有数据，且这些盐类在水中可自由离解，该小组从前述报告进行推断以支持安全性。该小组得出结论，二乙醇胺及其盐类在配方设计为无刺激性时使用是安全的。这些成分不应在可能形成N-亚硝基化合物的化妆品中使用。