梳状、温度可调且水溶的基于卟啉的温敏聚合物用于增强光动力疗法。
Comb-shaped, temperature-tunable and water-soluble porphyrin-based thermoresponsive copolymer for enhanced photodynamic therapy.
机构信息
School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China; School of Materials science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, China.
School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:155-162. doi: 10.1016/j.msec.2017.08.047. Epub 2017 Aug 12.
A novel comb-shaped porphyrin end-functionalized poly(N-isopropylacrylamide)-b-poly[oligo (ethylene glycol methyl ether methacrylate)] (Por-PNIPAM-b-POEGMA) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the incorporation of hydrophilic POEGMA contents, the copolymer shows the lower critical solution temperatures (LCST) of 37-41.8°C higher than PNIPAM. Moreover, this copolymer showed efficient singlet oxygen under light irradiation at 650nm, and the productivity of singlet oxygen was 0.59, which could be used for photodynamic therapy. In addition, the in vitro study indicated that this copolymer showed no significant dark cytotoxicity, while showed apparent photo-toxicity toward HeLa cancer cells under red light irradiation at 650nm. MTT results indicated that this copolymer with appropriate LCST could be accumulated on locally tumor tissues and killing of cancer cells (Hela), which may be a promising photosensitizer in photodynamic therapy for cancer treatment.
一种新型梳状卟啉端基功能化聚（N-异丙基丙烯酰胺）-b-聚[聚（乙二醇）甲基醚甲基丙烯酸酯]（Por-PNIPAM-b-POEGMA）通过可逆加成-断裂链转移（RAFT）聚合合成。由于亲水性 POEGMA 含量的掺入，共聚物的最低临界溶液温度（LCST）高于 PNIPAM 的 37-41.8°C。此外，该共聚物在 650nm 光照射下表现出高效的单线态氧，单线态氧的产率为 0.59，可用于光动力疗法。此外，体外研究表明，该共聚物在黑暗中无明显细胞毒性，而在 650nm 红光照射下对 HeLa 癌细胞表现出明显的光毒性。MTT 结果表明，这种具有适当 LCST 的共聚物可以在局部肿瘤组织中积累并杀死癌细胞（Hela），这可能是癌症光动力治疗中一种有前途的光敏剂。
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