Bose-Brill Seuli, Xing Jinming, Barnette Debra J, Hanks Christopher
Internal Medicine and Pediatrics at Grandview, Wexner Medical Center.
Department of Practice and Science, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Pharmgenomics Pers Med. 2017 Sep 25;10:247-252. doi: 10.2147/PGPM.S130247. eCollection 2017.
Adolescents with autism have higher rates of anxiety than the general adolescent population. They often struggle to express psychological symptoms verbally where their symptoms may manifest as withdrawal and agitation. Adolescent patients with autism have higher rates of polypharmacy and high-risk psychiatric medication use (eg, atypical antipsychotics) than other patients with psychiatric illness. Primary care pediatricians are at the front lines of psychiatric management for patients with autism. Yet, they have inadequate access to pediatric psychiatry for complex medication management. Pharmacogenomic testing can provide personalized drug metabolism profiles for a majority of psychotropic medications. Primary care based pharmacogenomic testing for adolescents with autism on one or more psychiatric medications may help individualize and optimize complex medication regimens, while promoting drug safety.
患有自闭症的青少年比普通青少年群体有更高的焦虑发生率。他们常常难以用言语表达心理症状，其症状可能表现为退缩和烦躁不安。与其他精神疾病患者相比，患有自闭症的青少年患者联合用药率更高，且使用高风险精神科药物（如非典型抗精神病药物）的比例也更高。初级保健儿科医生处于自闭症患者精神科管理的前沿。然而，他们在获取儿科精神病学专业知识以进行复杂药物管理方面存在不足。药物基因组检测可为大多数精神药物提供个性化的药物代谢谱。针对患有自闭症的青少年，基于初级保健进行一种或多种精神科药物的药物基因组检测，可能有助于使复杂的药物治疗方案个体化并实现优化，同时提高用药安全性。
