• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甲氨蝶呤所致白质脑病在急诊科表现为卒中

Methotrexate-induced leukoencephalopathy presenting as stroke in the emergency department.

作者信息

Cruz-Carreras Maria Teresa, Chaftari Patrick, Shamsnia Anna, Guha-Thakurta Nandita, Gonzalez Carmen

机构信息

Department of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.

出版信息

Clin Case Rep. 2017 Aug 29;5(10):1644-1648. doi: 10.1002/ccr3.1110. eCollection 2017 Oct.

DOI:10.1002/ccr3.1110
PMID:29026563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628205/
Abstract

Methotrexate-induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke-like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be IV or intrathecal and still results in leukoencephalopathy.

摘要

在任何接受甲氨蝶呤治疗后出现类中风症状的患者中，甲氨蝶呤诱导的白质脑病都应被视为一种潜在病因。我们的一个病例表明，甲氨蝶呤的给药方式可以是静脉注射或鞘内注射，并且仍然会导致白质脑病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6293/5628205/b26592f08822/CCR3-5-1644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6293/5628205/3c3a19a8c54d/CCR3-5-1644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6293/5628205/b26592f08822/CCR3-5-1644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6293/5628205/3c3a19a8c54d/CCR3-5-1644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6293/5628205/b26592f08822/CCR3-5-1644-g002.jpg

相似文献

1
Methotrexate-induced leukoencephalopathy presenting as stroke in the emergency department.甲氨蝶呤所致白质脑病在急诊科表现为卒中
Clin Case Rep. 2017 Aug 29;5(10):1644-1648. doi: 10.1002/ccr3.1110. eCollection 2017 Oct.
2
Methotrexate-Induced Leukoencephalopathy as a Clinical and Radiological Mimicker of Acute Ischemic Stroke Leading to Thrombolysis.甲氨蝶呤所致白质脑病作为急性缺血性卒中的临床和影像学模拟表现导致溶栓治疗
Cureus. 2024 Jan 2;16(1):e51542. doi: 10.7759/cureus.51542. eCollection 2024 Jan.
3
Methotrexate-induced acute toxic leukoencephalopathy.甲氨蝶呤诱导的急性中毒性白质脑病。
J Cancer Res Ther. 2012 Apr-Jun;8(2):292-6. doi: 10.4103/0973-1482.98993.
4
[Case of disseminated necrotizing leukoencephalopathy following intrathecal methotrexate in acute lymphocytic leukemia].[急性淋巴细胞白血病鞘内注射甲氨蝶呤后发生播散性坏死性白质脑病病例]
Gan No Rinsho. 1983 Feb;29(2):A-9, 138-42.
5
Neurotoxicity due to CNS therapy for leukemia.白血病中枢神经系统治疗引起的神经毒性。
Med Pediatr Oncol. 1977;3(1):101-15. doi: 10.1002/mpo.2950030114.
6
Sudden neurologic death after intrathecal methotrexate.鞘内注射甲氨蝶呤后突发神经源性死亡。
Med Pediatr Oncol. 1990;18(2):159-61. doi: 10.1002/mpo.2950180213.
7
Progression of methotrexate-induced leukoencephalopathy in children with leukemia.白血病患儿甲氨蝶呤诱导性白质脑病的进展
Med Pediatr Oncol. 1981;9(2):133-41. doi: 10.1002/mpo.2950090206.
8
A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.一种类似中风的病症：急诊科中氨甲蝶呤诱发的神经毒性
J Emerg Med. 2017 Apr;52(4):559-561. doi: 10.1016/j.jemermed.2016.11.016. Epub 2017 Jan 13.
9
[Acute methotrexate-related neurotoxicity and pseudo-stroke syndrome].[急性甲氨蝶呤相关神经毒性和假性中风综合征]
Arch Pediatr. 2017 Dec;24(12):1244-1248. doi: 10.1016/j.arcped.2017.09.024. Epub 2017 Nov 14.
10
Correlating pathology with the clinical symptoms of methotrexate-induced leukoencephalopathy in a child with relapsed T-cell acute lymphoblastic leukemia.一名复发性T细胞急性淋巴细胞白血病患儿甲氨蝶呤诱导的白质脑病的病理学与临床症状的相关性研究
J Pediatr Hematol Oncol. 2014 Jan;36(1):e19-22. doi: 10.1097/MPH.0b013e31827b6adb.

引用本文的文献

1
Acute therapy-related toxicities in pediatric acute lymphoblastic leukemia.小儿急性淋巴细胞白血病中与治疗相关的急性毒性反应
Haematologica. 2025 Sep 1;110(9):1923-1933. doi: 10.3324/haematol.2024.285702. Epub 2025 Mar 6.
2
Methotrexate-induced leukoencephalopathy presenting as acute-onset limb weakness in a child: a case report.甲氨蝶呤诱导的脑白质病致儿童急性起病的肢体无力：病例报告。
J Med Case Rep. 2024 Sep 28;18(1):475. doi: 10.1186/s13256-024-04824-5.
3
Complex Interplay between DNA Damage and Autophagy in Disease and Therapy.

本文引用的文献

1
A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.一种类似中风的病症：急诊科中氨甲蝶呤诱发的神经毒性
J Emerg Med. 2017 Apr;52(4):559-561. doi: 10.1016/j.jemermed.2016.11.016. Epub 2017 Jan 13.
2
Posterior reversible encephalopathy syndrome after intrathecal methotrexate infusion: a case report and literature update.鞘内注射甲氨蝶呤后发生的后部可逆性脑病综合征：一例报告及文献综述
Quant Imaging Med Surg. 2016 Oct;6(5):605-611. doi: 10.21037/qims.2016.10.07.
3
The double-edged sword: Neurotoxicity of chemotherapy.
DNA 损伤与自噬在疾病与治疗中的复杂相互作用。
Biomolecules. 2024 Jul 29;14(8):922. doi: 10.3390/biom14080922.
4
Methotrexate-Induced Leukoencephalopathy as a Clinical and Radiological Mimicker of Acute Ischemic Stroke Leading to Thrombolysis.甲氨蝶呤所致白质脑病作为急性缺血性卒中的临床和影像学模拟表现导致溶栓治疗
Cureus. 2024 Jan 2;16(1):e51542. doi: 10.7759/cureus.51542. eCollection 2024 Jan.
5
Recurrence of methotrexate-induced leukoencephalopathy after methotrexate rechallenge: A case report and literature review.甲氨蝶呤再次给药后甲氨蝶呤诱导的白质脑病复发：一例报告及文献综述
Radiol Case Rep. 2022 Dec 19;18(3):799-804. doi: 10.1016/j.radcr.2022.11.057. eCollection 2023 Mar.
6
The Clinical Impact of Methotrexate-Induced Stroke-Like Neurotoxicity in Paediatric Departments: An Italian Multi-Centre Case-Series.甲氨蝶呤诱导的类中风神经毒性在儿科的临床影响：一项意大利多中心病例系列研究
Front Neurol. 2022 Jun 10;13:920214. doi: 10.3389/fneur.2022.920214. eCollection 2022.
7
Fatal multiorgan dysfunction following repeated iodinated radiocontrast injection in a patient receiving low-dose oral methotrexate -a case report.患者接受低剂量口服甲氨蝶呤治疗期间，重复使用碘造影剂后发生致命性多器官功能障碍：病例报告。
Korean J Anesthesiol. 2022 Jun;75(3):283-285. doi: 10.4097/kja.22067. Epub 2022 Mar 14.
8
Toxic and metabolic leukoencephalopathies in emergency department patients: a primer for the radiologist.急诊科中毒性和代谢性脑白质病患者：放射科医生入门。
Emerg Radiol. 2022 Jun;29(3):545-555. doi: 10.1007/s10140-022-02032-6. Epub 2022 Feb 24.
9
Subacute neurological deficits and respiratory insufficiency due to intrathecal methotrexate.鞘内注射甲氨蝶呤导致的亚急性神经功能缺损和呼吸功能不全。
J Clin Transl Res. 2021 Nov 29;7(6):809-810. eCollection 2021 Dec 28.
10
Methotrexate-induced toxic leukoencephalopathy: an uncommon stroke mimic.甲氨蝶呤诱发的中毒性白质脑病：一种罕见的类似中风的病症。
Neurol Sci. 2019 Jun;40(6):1307-1309. doi: 10.1007/s10072-019-3711-4. Epub 2019 Jan 13.
双刃剑：化疗的神经毒性
Blood Rev. 2015 Mar;29(2):93-100. doi: 10.1016/j.blre.2014.09.012. Epub 2014 Sep 28.
4
Review of dextromethorphan administration in 18 patients with subacute methotrexate central nervous system toxicity.18例亚急性甲氨蝶呤中枢神经系统毒性患者右美沙芬给药情况回顾。
Pediatr Neurol. 2014 Jun;50(6):625-9. doi: 10.1016/j.pediatrneurol.2014.01.048. Epub 2014 Jan 31.
5
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.甲氨蝶呤诱导的儿童急性淋巴细胞白血病的神经毒性和脑白质病。
J Clin Oncol. 2014 Mar 20;32(9):949-59. doi: 10.1200/JCO.2013.53.0808. Epub 2014 Feb 18.
6
Methotrexate induced leucoencephalopathy: A stroke mimic.甲氨蝶呤诱发的白质脑病：一种类似中风的病症。
Ann Indian Acad Neurol. 2013 Jul;16(3):418-21. doi: 10.4103/0972-2327.116922.
7
Methotrexate-induced acute toxic leukoencephalopathy.甲氨蝶呤诱导的急性中毒性白质脑病。
J Cancer Res Ther. 2012 Apr-Jun;8(2):292-6. doi: 10.4103/0973-1482.98993.
8
Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke.鞘内注射甲氨蝶呤后酷似中风的短暂性白质脑病。
Emerg Radiol. 2011 Aug;18(4):345-7. doi: 10.1007/s10140-010-0931-6. Epub 2011 Jan 18.
9
Reversible acute methotrexate leukoencephalopathy: atypical brain MR imaging features.可逆性急性甲氨蝶呤白质脑病：非典型脑磁共振成像特征
Pediatr Radiol. 2006 Mar;36(3):205-12. doi: 10.1007/s00247-005-0015-z. Epub 2005 Dec 21.
10
Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate.接受大剂量甲氨蝶呤治疗的急性淋巴细胞白血病患儿中脑白质病的患病率。
AJNR Am J Neuroradiol. 2005 May;26(5):1263-9.