Simoens C, Woussen-Colle M C, De Graef J
Department of Surgery, University Hospital Saint-Pierre, Free University of Brussels, Belgium.
Regul Pept. 1988 Aug;22(3):285-93. doi: 10.1016/0167-0115(88)90041-9.
During a first series of experiments, the gastrin responses to a meal were measured and compared to the responses seen after administration of cimetidine (2.5 mg/kg/h) or omeprazole (2 mg/kg). During a second series of experiments the effects of cimetidine (2.5 mg/kg/h), ranitidine (0.5 mg/kg/h) and omeprazole (2 mg/kg) on post-prandial gastrin and somatostatin release were determined in experiments during which the intragastric pH was maintained close to 6.4. During a third series of experiments, the effects of cimetidine (2.5 mg/kg/h) and omeprazole (2 mg/kg) on basal gastrin and somatostatin release were estimated. Postprandial gastrin release was increased by cimetidine and by omeprazole. When acidification of the gastric content was prevented by intragastric titration, postprandial gastrin release was increased by about 100%. No further increase was observed when the animals were concomitantly treated with cimetidine, ranitidine or omeprazole. Intragastric titration did not alter postprandial somatostatin release. Concomitant administration of H2 blockers decreased the somatostatin response to the meal, while concomitant administration of omeprazole did not alter this release. No significant changes were observed in basal gastrin or somatostatin levels after administration of cimetidine or omeprazole.(ABSTRACT TRUNCATED AT 250 WORDS)
在第一组实验中，测量了胃泌素对进食的反应，并与给予西咪替丁（2.5毫克/千克/小时）或奥美拉唑（2毫克/千克）后观察到的反应进行比较。在第二组实验中，在胃内pH值维持在接近6.4的实验中，确定了西咪替丁（2.5毫克/千克/小时）、雷尼替丁（0.5毫克/千克/小时）和奥美拉唑（2毫克/千克）对餐后胃泌素和生长抑素释放的影响。在第三组实验中，评估了西咪替丁（2.5毫克/千克/小时）和奥美拉唑（2毫克/千克）对基础胃泌素和生长抑素释放的影响。西咪替丁和奥美拉唑均可增加餐后胃泌素释放。当通过胃内滴定防止胃内容物酸化时，餐后胃泌素释放增加约100%。当动物同时接受西咪替丁、雷尼替丁或奥美拉唑治疗时，未观察到进一步增加。胃内滴定未改变餐后生长抑素释放。同时给予H2受体阻滞剂可降低生长抑素对进食的反应，而同时给予奥美拉唑则不改变这种释放。给予西咪替丁或奥美拉唑后，基础胃泌素或生长抑素水平未观察到显著变化。（摘要截短至250字）
