替加环素作为重症军团病患者的二线治疗药物
Tigecycline as a Second-Line Agent for Legionnaires' Disease in Severely Ill Patients.
作者信息
Slawek Deepika, Altshuler Diana, Dubrovskaya Yanina, Louie Eddie
机构信息
Division of Infectious Diseases, NYU Langone Medical Center, New York, New York.
Department of Pharmacy, NYU Langone Medical Center, New York, New York.
出版信息
Open Forum Infect Dis. 2017 Oct 7;4(4):ofx184. doi: 10.1093/ofid/ofx184. eCollection 2017 Fall.
Abstract
Treatment of Legionnaires' disease in severely ill or immunosuppressed patients presents a clinical challenge. Tigecycline (TG) achieves high concentrations intracellularly and has been shown to be effective against in animal and cell models. We report our experience using TG as second-line therapy. Clinical response was seen in most patients after switching to TG alone or as a combination therapy.
摘要
对重症或免疫抑制患者的军团病进行治疗是一项临床挑战。替加环素（TG）在细胞内可达到高浓度，并且在动物和细胞模型中已显示出对（原文此处似乎缺失部分内容）有效。我们报告了使用TG作为二线治疗的经验。在改用单独使用TG或联合治疗后，大多数患者出现了临床反应。
相似文献
1
Tigecycline as a Second-Line Agent for Legionnaires' Disease in Severely Ill Patients.替加环素作为重症军团病患者的二线治疗药物
Open Forum Infect Dis. 2017 Oct 7;4(4):ofx184. doi: 10.1093/ofid/ofx184. eCollection 2017 Fall.
2
Successful Treatment of Legionnaires' Disease with Tigecycline in an Immunocompromised Man with a Legion of Antibiotic Allergies.替加环素成功治疗一名患有多种抗生素过敏的免疫功能低下男性的军团菌病。
Cureus. 2019 Apr 30;11(4):e4577. doi: 10.7759/cureus.4577.
3
An update on Legionella.军团菌更新。
Curr Opin Infect Dis. 2010 Apr;23(2):152-7. doi: 10.1097/QCO.0b013e328336835b.
4
A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks.一种用于在疫情期间准确进行嗜肺军团菌来源归因的监督式统计学习方法。
Appl Environ Microbiol. 2017 Oct 17;83(21). doi: 10.1128/AEM.01482-17. Print 2017 Nov 1.
5
Intracellular multiplication of Legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin.军团病细菌（嗜肺军团菌）在人单核细胞内的繁殖可被红霉素和利福平可逆性抑制。
J Clin Invest. 1983 Jan;71(1):15-26. doi: 10.1172/jci110744.
6
Nosocomial Legionnaires' disease.医院获得性军团菌病
Zhonghua Yi Xue Za Zhi (Taipei). 1989 Oct;44(4):242-8.
7
Probable reinfection with Legionella pneumophila - A case report.可能由嗜肺军团菌引起的再感染：一例报告。
Int J Hyg Environ Health. 2019 Mar;222(2):315-318. doi: 10.1016/j.ijheh.2018.11.001. Epub 2018 Nov 27.
8
[Legionnaires' disease in travellers].[旅行者中的军团病]
Bull Soc Pathol Exot. 1998;91(5 Pt 1-2):486-9.
9
Legionnaires' disease - Results of a multicentre Canadian study.军团病——加拿大一项多中心研究的结果。
Can J Infect Dis. 2003 May;14(3):154-8. doi: 10.1155/2003/951567.
10
Cell-mediated immunity in Legionnaires' disease.军团病中的细胞介导免疫。
J Clin Invest. 1983 Jun;71(6):1686-97. doi: 10.1172/jci110923.
引用本文的文献
1
Omadacycline for the Treatment of Severe Pneumonia Complicated with Multiple Organ Failure: A Case Report.奥马环素治疗重症肺炎合并多器官功能衰竭：一例报告
Int Med Case Rep J. 2025 Feb 1;18:217-222. doi: 10.2147/IMCRJ.S498539. eCollection 2025.
2
Antibiotic susceptibility pattern of Portuguese environmental Legionella isolates.葡萄牙环境军团菌分离株的抗生素药敏模式。
Front Cell Infect Microbiol. 2023 Apr 21;13:1141115. doi: 10.3389/fcimb.2023.1141115. eCollection 2023.
3
Diagnosis and Treatment of Water-Contaminated Severe Legionella Pneumonia with Digestive Symptoms as the First Symptom: A Case Report and Review of the Literature.以消化症状为首发症状的水源污染重症军团菌肺炎的诊断与治疗：一例报告并文献复习
Infect Drug Resist. 2023 Jan 18;16:323-328. doi: 10.2147/IDR.S394965. eCollection 2023.
4
Successful Treatment of Legionnaires' Disease with Tigecycline in an Immunocompromised Man with a Legion of Antibiotic Allergies.替加环素成功治疗一名患有多种抗生素过敏的免疫功能低下男性的军团菌病。
Cureus. 2019 Apr 30;11(4):e4577. doi: 10.7759/cureus.4577.
本文引用的文献
1
The association of antibiotic treatment regimen and hospital mortality in patients hospitalized with Legionella pneumonia.抗生素治疗方案与军团菌肺炎住院患者的医院死亡率的相关性。
Clin Infect Dis. 2015 Jun 1;60(11):e66-79. doi: 10.1093/cid/civ157. Epub 2015 Feb 25.
2
Tigecycline as a therapeutic option in Stenotrophomonas maltophilia infections.替加环素作为嗜麦芽窄食单胞菌感染的一种治疗选择。
J Chemother. 2012 Jun;24(3):150-4. doi: 10.1179/1120009X12Z.00000000022.
3
4
Activities of tigecycline and comparators against Legionella pneumophila and Legionella micdadei extracellularly and in human monocyte-derived macrophages.替加环素及对照药物对嗜肺军团菌和米克戴德军团菌的体外活性及在人单核细胞衍生巨噬细胞中的活性。
Diagn Microbiol Infect Dis. 2011 Jan;69(1):86-93. doi: 10.1016/j.diagmicrobio.2010.08.023.
5
Disseminated Legionella pneumophila infection in an immunocompromised patient treated with tigecycline.一名接受替加环素治疗的免疫功能低下患者发生播散性嗜肺军团菌感染。
Scand J Infect Dis. 2010;42(2):152-5. doi: 10.3109/00365540903359895.
6
Treatment strategies for Legionella infection.军团菌感染的治疗策略。
Expert Opin Pharmacother. 2009 May;10(7):1109-21. doi: 10.1517/14656560902900820.
7
Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia.替加环素（GAR-936）对嗜肺军团菌的体外活性以及在豚鼠嗜肺军团菌肺炎模型中的活性。
Antimicrob Agents Chemother. 2003 Feb;47(2):533-40. doi: 10.1128/AAC.47.2.533-540.2003.
8
Legionella and Legionnaires' disease: 25 years of investigation.军团菌与军团病：25年的研究历程
Clin Microbiol Rev. 2002 Jul;15(3):506-26. doi: 10.1128/CMR.15.3.506-526.2002.
9
Legionellosis.军团病
N Engl J Med. 1997 Sep 4;337(10):682-7. doi: 10.1056/NEJM199709043371006.
10
Antimicrobial chemotherapy for legionnaires' disease: a review.军团病的抗菌化疗：综述
Clin Infect Dis. 1995 Dec;21 Suppl 3:S265-76. doi: 10.1093/clind/21.supplement_3.s265.
Zotero 插件