[雌激素诱导多种肝脏酶活性增加的发展及意义]
[Development and significance of estrogen-induced increase in the activity of several liver enzymes].
作者信息
Németh S
机构信息
Institut für experimentelle Endokrinologie, Bratislava/CSSR.
出版信息
Z Gesamte Inn Med. 1988 Aug 1;43(15):418-20.
PMID:2902713
Abstract
In experiments on adult, female rats, the author confirm the stimulatory effect of 50 micrograms kg-1 17-beta-estradiol daily, s.c., for more than 1 week on the activity of liver tyrosine aminotransferase and tryptophan pyrrolase and describe experiments suggesting an increased glucocorticoid sensitivity, as a consequence of the estrogen treatment. The study contributes to the information on potential side effects of hormonal contraception.
摘要
在对成年雌性大鼠进行的实验中，作者证实，每天皮下注射50微克/千克的17-β-雌二醇，持续1周以上，可刺激肝脏酪氨酸转氨酶和色氨酸吡咯酶的活性，并描述了一些实验，这些实验表明雌激素治疗会导致糖皮质激素敏感性增加。该研究有助于了解激素避孕的潜在副作用。
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