Haler Jean R N, Massonnet Philippe, Chirot Fabien, Kune Christopher, Comby-Zerbino Clothilde, Jordens Jan, Honing Maarten, Mengerink Ynze, Far Johann, Dugourd Philippe, De Pauw Edwin
Mass Spectrometry Laboratory, University of Liège, Quartier Agora, Allée du Six Aout 11, B-4000, Liège, Belgium.
Institut des Sciences Analytiques, Université de Lyon, Université Lyon1, Ens de Lyon, CNRS, 69100, Villeurbanne, France.
J Am Soc Mass Spectrom. 2018 Jan;29(1):114-120. doi: 10.1007/s13361-017-1822-9. Epub 2017 Oct 12.
Over the years, polymer analyses using ion mobility-mass spectrometry (IM-MS) measurements have been performed on different ion mobility spectrometry (IMS) setups. In order to be able to compare literature data taken on different IM(-MS) instruments, ion heating and ion temperature evaluations have already been explored. Nevertheless, extrapolations to other analytes are difficult and thus straightforward same-sample instrument comparisons seem to be the only reliable way to make sure that the different IM(-MS) setups do not greatly change the gas-phase behavior. We used a large range of degrees of polymerization (DP) of poly(ethylene oxide) PEO homopolymers to measure IMS drift times on three different IM-MS setups: a homemade drift tube (DT), a trapped (TIMS), and a traveling wave (T-Wave) IMS setup. The drift time evolutions were followed for increasing polymer DPs (masses) and charge states, and they are found to be comparable and reproducible on the three instruments. ᅟ.
多年来，已在不同的离子迁移谱（IMS）装置上使用离子迁移率-质谱（IM-MS）测量进行了聚合物分析。为了能够比较在不同IM（-MS）仪器上获取的文献数据，已经探索了离子加热和离子温度评估。然而，将结果外推到其他分析物很困难，因此直接进行同一样品的仪器比较似乎是确保不同IM（-MS）装置不会极大改变气相行为的唯一可靠方法。我们使用了一系列不同聚合度（DP）的聚环氧乙烷（PEO）均聚物，在三种不同的IM-MS装置上测量IMS漂移时间：自制漂移管（DT）、捕集离子淌度谱（TIMS）和行波（T-Wave）IMS装置。随着聚合物DP（质量）和电荷态的增加，跟踪了漂移时间的变化，并且发现它们在这三种仪器上具有可比性和可重复性。
