Sautel M, Sacquet J, Vincent M, Sassard J
Department of Physiology and Clinical Pharmacology, Centre National de la Recherche Scientique, (UA 606), Faculty of Pharmacy, Lyon, France.
Am J Physiol. 1988 Oct;255(4 Pt 2):H729-35. doi: 10.1152/ajpheart.1988.255.4.H729.
Several indirect evidences of alterations in the central catecholaminergic structures were obtained in genetically hypertensive rats. Because they could be of pathogenetic value, we measured, in the present work, the in vivo turnover (TO) of norepinephrine (NE) in brain areas of 5- and 22-wk-old genetically hypertensive (LH) rats of the Lyon strain, and their simultaneously selected normotensive (LN) and low blood pressure (LL) controls. Among the changes observed, the increased TO of NE in the A2 and A6 regions of 5-wk-old LH rats and its decrease in the posteroventral hypothalamic nucleus of 22-wk-old LH animals appeared likely to compensate for hypertension. On the contrary, the decreased TO of NE in the anterior hypothalamic nucleus observed at 5 wk and in the A6 and A1 areas at 22 wk of age in LH rats could participate in the development or the maintenance of hypertension. Above all, it was postulated that the increased TO of NE found in the A7 region of 5-wk-old LH rats could play a primary role in the pathogenesis of hypertension in the Lyon model.
在遗传性高血压大鼠中获得了一些关于中枢儿茶酚胺能结构改变的间接证据。由于它们可能具有致病价值，因此在本研究中，我们测量了5周龄和22周龄的Lyon品系遗传性高血压（LH）大鼠脑区中去甲肾上腺素（NE）的体内周转率（TO），以及同时选取的正常血压（LN）和低血压（LL）对照。在所观察到的变化中，5周龄LH大鼠A2和A6区域NE的TO增加，而22周龄LH动物下丘脑后腹核中NE的TO降低，这似乎是对高血压的一种代偿。相反，LH大鼠在5周龄时下丘脑前核以及22周龄时A6和A1区域NE的TO降低可能参与了高血压的发生或维持。最重要的是，推测5周龄LH大鼠A7区域中NE的TO增加可能在Lyon模型高血压发病机制中起主要作用。
