Zhang Yanmin, Ding Yuanqi, Xie Lei, Ma Honghong, Yao Xinyi, Zhang Chi, Yuan Chunxue, Xu Wei
Interdisciplinary Materials Research Center, Tongji-Aarhus Joint Research Center for Nanostructures and Functional Nanomaterials, College of Materials Science and Engineering, Tongji University, Caoan Road 4800, Shanghai, 201804, P. R. China.
Chemphyschem. 2017 Dec 15;18(24):3544-3547. doi: 10.1002/cphc.201701009. Epub 2017 Nov 15.
Despite the fact that DNA bases have been well-studied on surface, the on-surface synthesis of one-dimensional DNA analogs through in situ reactions is still an interesting topic to be investigated. Herein, from the interplay of high-resolution scanning tunneling microscopy (STM) imaging and density functional theory (DFT) calculations, we have delicately designed a halogenated derivative of adenine as precursor to realize the combination of DNA bases and Ullmann reaction, and then successfully synthesized adenine oligomers on Au(111) via Ullmann coupling. This model system provides a possible bottom-up strategy of fabricating adenine oligomers on surface, which may further give access to man-made DNA strands with multiple bases.
尽管DNA碱基在表面已得到充分研究，但通过原位反应在表面合成一维DNA类似物仍是一个有待研究的有趣课题。在此，通过高分辨率扫描隧道显微镜（STM）成像与密度泛函理论（DFT）计算的相互作用，我们精心设计了一种腺嘌呤卤代衍生物作为前体，以实现DNA碱基与乌尔曼反应的结合，然后通过乌尔曼偶联在Au(111)上成功合成了腺嘌呤低聚物。该模型系统提供了一种在表面制备腺嘌呤低聚物的自下而上的可能策略，这可能进一步通向具有多个碱基的人造DNA链。
