Ueda K, Komano T
Dept. of Agricultural Chemistry Kyoto University.
Gan To Kagaku Ryoho. 1988 Oct;15(10):2858-62.
MDR1 gene encodes a membrane glycoprotein (P-glycoprotein) that acts as a energy-dependent pump to transport antitumor drugs out of the cells. P-glycoprotein, 1280 amino acids long, consists of two homologous parts of approximately equal length. The protein has binding sites for ATP, antitumor drugs and calcium channel blockers. MDR1 gene is expressed tissue-specific in human normal adrenal, kidney, liver and colon. The normal function and transcriptional regulation of this gene are also discussed.
多药耐药基因1（MDR1）编码一种膜糖蛋白（P-糖蛋白），它作为一种能量依赖性泵将抗肿瘤药物转运出细胞。P-糖蛋白由1280个氨基酸组成，包含两个长度大致相等的同源部分。该蛋白具有ATP、抗肿瘤药物和钙通道阻滞剂的结合位点。MDR1基因在人类正常肾上腺、肾脏、肝脏和结肠中呈组织特异性表达。本文还讨论了该基因的正常功能和转录调控。
