Bier H, Bergler W, Mende S, Ganzer U
ENT Department Klinikum Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Federal Republic of Germany.
Arch Otorhinolaryngol. 1988;245(3):166-9. doi: 10.1007/BF00464020.
Drug resistance is a major problem in chemotherapy of squamous cell head and neck cancers (SCHNC). Since glutathione (GSH) plays a crucial role in mediating tumor cell resistance against various toxic insults, GSH metabolism in SCHNC xenografts was investigated. Xenografts from lymph node metastases contained markedly higher GSH concentrations compared with those derived from the corresponding primary lesions. After subcurative chemotherapy with cisplatin (DDP), a significant increase of both GSH levels and gamma-glutamyltranspeptidase activity (gamma-GT) was gained in tumor HT1M. Tumor HT3M showed high concentrations of GSH and gamma-GT, although these latter concentrations did not increase following chemotherapy with DDP. These findings suggest a possible impact of GSH metabolism on both the formation of metastases and the phenomenon of drug resistance in SCHNC.
耐药性是头颈部鳞状细胞癌（SCHNC）化疗中的一个主要问题。由于谷胱甘肽（GSH）在介导肿瘤细胞对各种毒性损伤的抗性中起关键作用，因此对SCHNC异种移植瘤中的GSH代谢进行了研究。与相应原发性病变来源的异种移植瘤相比，淋巴结转移来源的异种移植瘤中GSH浓度明显更高。在用顺铂（DDP）进行亚根治性化疗后，肿瘤HT1M中的GSH水平和γ-谷氨酰转肽酶活性（γ-GT）均显著增加。肿瘤HT3M显示出高浓度的GSH和γ-GT，尽管在用DDP化疗后这些浓度没有增加。这些发现表明GSH代谢可能对头颈部鳞状细胞癌转移的形成和耐药现象都有影响。
