Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory of Diagnostic and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Rehabilitation, The Third Hospital of Zhejiang University of Chinese Medicine, Hangzhou, China.
J Affect Disord. 2018 Jan 15;226:307-312. doi: 10.1016/j.jad.2017.10.002. Epub 2017 Oct 3.
Psychiatric diseases are usually accompanied by immune dysregulation and activation of the inflammatory response system. However, the characteristics of immunoinflammatory markers in psychiatric diseases are not well defined.
Seventy-three patients with psychiatric diseases were divided into four groups, including a schizophrenia group, an anxiety disorder group, a unipolar depression group, and a bipolar disorder group, according to the ICD-10 and DSM-IV codes. Neutrophil gelatinase-associated lipocalin (NGAL) and associated classical immunoinflammatory markers including C-reactive protein (CRP), Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ), total leukocyte count (TLC), and neutrophilic granulocyte percentage (NEU%) were analysed; patients with physical diseases were excluded to avoid confounders. Fifteen healthy, age- and gender-matched individuals served as controls.
Compared with the corresponding values in the control group, the level of CRP in each psychiatric disease group, the levels of IFN-γ and NGAL in the schizophrenia group, and the NEU% in the depression group were significantly elevated (P < 0.05). Compared with the levels in the schizophrenia group, the levels of CRP in the bipolar disorder and depression groups, the level of IFN-γ in the bipolar disorder group, and the levels of NGAL in the anxiety disorder and depression groups were significantly decreased (P < 0.05). Compared with the depression group, the bipolar disorder group showed significant elevation the NGAL level.
The sample size was relatively small.
Immunoinflammatory markers were elevated in patients with psychiatric diseases, especially schizophrenia. We are the first to report that the level of NGAL is significantly increased in schizophrenia patients.
精神疾病通常伴随着免疫失调和炎症反应系统的激活。然而，精神疾病的免疫炎症标志物特征尚未得到很好的定义。
根据 ICD-10 和 DSM-IV 编码，将 73 例精神疾病患者分为精神分裂症组、焦虑障碍组、单相抑郁症组和双相情感障碍组 4 组。分析中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和相关经典免疫炎症标志物，包括 C 反应蛋白（CRP）、Th1/Th2 细胞因子（IL-2、IL-4、IL-6、IL-10、TNF-α和 IFN-γ）、总白细胞计数（TLC）和中性粒细胞百分比（NEU%）；排除有躯体疾病的患者，以避免混杂因素。15 名年龄和性别相匹配的健康个体作为对照。
与对照组相应值相比，各精神疾病组的 CRP 水平、精神分裂症组的 IFN-γ和 NGAL 水平、抑郁症组的 NEU%水平均显著升高（P<0.05）。与精神分裂症组相比，双相情感障碍组和抑郁症组的 CRP 水平、双相情感障碍组的 IFN-γ水平、焦虑障碍组和抑郁症组的 NGAL 水平均显著降低（P<0.05）。与抑郁症组相比，双相情感障碍组的 NGAL 水平显著升高。
样本量相对较小。
精神疾病患者的免疫炎症标志物升高，尤其是精神分裂症。我们首次报道精神分裂症患者的 NGAL 水平显著升高。
