先天性心脏病中的急性肾损伤
Acute kidney injury in congenital heart disease.
作者信息
Gist Katja M, Kwiatkowski David M, Cooper David S
机构信息
The Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, Colorado.
Division of Cardiology, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California.
出版信息
Curr Opin Cardiol. 2018 Jan;33(1):101-107. doi: 10.1097/HCO.0000000000000473.
PURPOSE OF REVIEW
Acute kidney injury (AKI) is associated with significant morbidity and mortality in patients with congenital heart disease undergoing cardiac surgery or in pediatric patients with congestive heart failure.
RECENT FINDINGS
This review describes the definition and various manifestations of AKI, the impact of biomarkers on the diagnosis of AKI, the importance of fluid overload as a consequence of AKI and its long-term impact.
SUMMARY
There are novel biomarkers for AKI detection that should facilitate early recognition and intervention to prevent or attenuate the effects of AKI and fluid overload. Previous conventional wisdom that survivors of AKI fully recover renal function without subsequent consequences is flawed.
综述目的
急性肾损伤（AKI）与接受心脏手术的先天性心脏病患者或患有充血性心力衰竭的儿科患者的显著发病率和死亡率相关。
最新发现
本综述描述了AKI的定义和各种表现、生物标志物对AKI诊断的影响、AKI导致的液体超负荷的重要性及其长期影响。
总结
有用于检测AKI的新型生物标志物，这应有助于早期识别和干预，以预防或减轻AKI和液体超负荷的影响。以往认为AKI幸存者肾功能能完全恢复且无后续影响的传统观念是有缺陷的。
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