From the aDepartment of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan, Republic of China; bDepartment of Occupational Therapy, College of Medical and Health Science, Asia University, Taichung, Taiwan, Republic of China.
Epidemiology. 2017 Oct;28 Suppl 1:S126-S132. doi: 10.1097/EDE.0000000000000741.
Allergic rhinitis (AR) is a highly prevalent chronic inflammatory disease affecting nearly 40% of the children in Taiwan. Genetic susceptibility may interact with specific environmental factors leading to allergic disease development.
To assess the interactions between catalase gene promoter polymorphisms and environmental factors on the risk of AR, we conducted a case-control study in Taiwan. Data on AR and environmental factors were collected from 800 children using the ISSAC questionnaire. The case group consisted of 263 children with AR, and the control group consisted of =537 healthy children. Genotyping was performed for rs1001179 and rs769214 polymorphisms, and environmental exposure was assessed using four indicators including dwelling visible molds, mold odor, moisture on surfaces, and water damage.
We found that the presence of visible molds, mold odor, and moisture was associated with AR. An apparent joint effect of the GG genotype and mold odor, compared with the AA and AG combined genotypes and without any exposure indicator (adjusted odds ratio [OR] = 1.95 [95% confidence interval (CI) = 1.20, 3.18]; interaction adjusted odds ratio = 2.59 [95% CI = 1.27, 5.30]), was observed.
Our findings suggest that gene-environment interactions between the catalase polymorphism rs769214 and mold odor may play an important role in childhood AR development.
变应性鼻炎（AR）是一种高发的慢性炎症性疾病，影响了近 40%的台湾儿童。遗传易感性可能与特定的环境因素相互作用，导致过敏疾病的发展。
为了评估过氧化氢酶基因启动子多态性与环境因素之间的相互作用是否会增加 AR 的发病风险，我们在台湾进行了一项病例对照研究。采用 ISAAC 问卷调查表收集了 800 名儿童的 AR 及环境因素数据。病例组由 263 名 AR 患儿组成，对照组由 537 名健康儿童组成。对 rs1001179 和 rs769214 多态性进行基因分型，采用 4 个指标评估环境暴露，包括居住处可见霉菌、霉菌气味、表面潮湿和水渍。
我们发现可见霉菌、霉菌气味和潮湿与 AR 有关。与 AA 和 AG 组合基因型且没有任何暴露指标相比，GG 基因型和霉菌气味同时存在时，AR 的风险明显增加（调整后的比值比 [OR] = 1.95[95%置信区间（CI）= 1.20，3.18]；调整后的交互作用 OR = 2.59[95% CI = 1.27，5.30]）。
我们的研究结果表明，过氧化氢酶多态性 rs769214 与霉菌气味之间的基因-环境相互作用可能在儿童 AR 的发病机制中起重要作用。
