Alegría Anselmo, Irarrázaval Sebastián
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Proyecto Epistemonikos, Santiago, Chile; Departamento de Traumatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email:
Medwave. 2017 Oct 12;17(8):e7041. doi: 10.5867/medwave.2017.08.7041.
Among the possibilities for the management of osteoarthritis, different pharmacological alternatives have been proposed, being diacerein one of them due to its anti-inflammatory effect. However, diacerein clinical utility is not clear.
To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.
We concluded diacerein may lead to a slight reduction in pain and probably not improve functionality among patients with knee osteoarthritis and can frequently present diarrhea as an adverse effect. [corrected].
在骨关节炎的治疗方法中，已经提出了不同的药物选择，双醋瑞因因其抗炎作用而成为其中之一。然而，双醋瑞因的临床效用尚不清楚。
为了回答这个问题，我们使用了Epistemonikos，这是最大的健康系统评价数据库，通过筛选多个信息来源进行维护，包括MEDLINE、EMBASE、Cochrane等。我们从系统评价中提取数据，重新分析了原始研究的数据，进行了荟萃分析，并使用GRADE方法生成了结果总结表。
我们得出结论，双醋瑞因可能会使膝关节骨关节炎患者的疼痛略有减轻，但可能无法改善其功能，并且经常会出现腹泻作为不良反应。[已修正]
