Ukai M, Holtzman S G
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.
Brain Res. 1988 Sep 6;459(2):275-81. doi: 10.1016/0006-8993(88)90643-9.
The effects of opioid peptides selective for mu, kappa, and delta-opioid receptors were investigated on 3 different schedules of water intake in the rat: spontaneous, deprivational (12 h), and hypertonic saline-induced drinking. Peptides were injected into the paraventricular and supraoptic hypothalamic nuclei, D-Ala2-NMePhe4-Gly(ol)-enkephalin, a mu-selective opioid agonist, tended to increase water intake in non-deprived rats, but 0.01 and 0.1 microgram significantly decreased water intake for 45 min in deprived rats, and for up to 60 min in hypertonic saline-injected rats when injected into the paraventricular hypothalamic nucleus. The kappa-selective agonist, dynorphin A1-13 (0.1, 0.3, 1.0 and 3.0 micrograms)and the delta-selective agonist, [D-Pen2,L-Pen5]enkephalin (0.3 and 3.0 micrograms) did not affect spontaneous, deprivational or hypertonic saline-induced water intakes when injected into either the paraventricular or supraoptic hypothalamic nuclei. Thus, a mu-selective opioid peptide produced dose- and time-dependent effects on drinking that were pharmacologically and anatomically specific, and dependent upon the schedule of water intake.
研究了对μ、κ和δ阿片受体有选择性的阿片肽对大鼠三种不同饮水模式的影响：自由饮水、剥夺饮水（12小时）和高渗盐水诱导饮水。将肽注射到下丘脑室旁核和视上核，μ选择性阿片激动剂D-Ala2-NMePhe4-Gly(ol)-脑啡肽，在未剥夺饮水的大鼠中倾向于增加饮水量，但当注射到下丘脑室旁核时，0.01微克和0.1微克剂量可使剥夺饮水的大鼠在45分钟内饮水量显著减少，使注射高渗盐水的大鼠在长达60分钟内饮水量显著减少。κ选择性激动剂强啡肽A1-13（0.1、0.3、1.0和3.0微克）和δ选择性激动剂[D-Pen2,L-Pen5]脑啡肽（0.3和3.0微克），无论注射到下丘脑室旁核还是视上核，均不影响自由饮水、剥夺饮水或高渗盐水诱导的饮水量。因此，μ选择性阿片肽对饮水产生了剂量和时间依赖性影响，这些影响在药理学和解剖学上具有特异性，并且取决于饮水模式。
