Chen Tuo-Yu, Lee Soomi, Buxton Orfeu M
Centre for Ageing Research and Education, Duke-NUS Medical School, Singapore.
Center for Healthy Aging, Pennsylvania State University, University Park, PA.
Sleep. 2017 Nov 1;40(11). doi: 10.1093/sleep/zsx142.
Cross-sectional studies suggest that insomnia symptoms are associated with falls in later life. This longitudinal study examines the independent and interactive effects of the extent of insomnia symptoms (i.e., multiple co-existing insomnia symptoms) and sleep medications on fall risk over a 2-year follow-up among community-dwelling older adults.
Using data from the Health and Retirement Study (2006-2014, N = 6882, Mage = 74.5 years ± 6.6 years), we calculated the extent of insomnia symptoms (range = 0-4) participants reported (i.e., trouble falling asleep, waking up during the night, waking up too early, and not feeling rested). At each wave, participants reported recent sleep medications use and falls since the last wave, and were evaluated for balance and walking speed.
A greater burden of insomnia symptoms and using physician-recommended sleep medications at baseline independently predicted falling after adjusting for known risk factors of falling. The effects of insomnia symptoms on fall risk differed by sleep medications use. The extent of insomnia symptoms exhibited a positive, dose-response relation with risk of falling among those not using sleep medications. Older adults using physician-recommended sleep medications exhibited a consistently higher fall risk irrespective of the extent of insomnia symptoms.
The number of insomnia symptoms predicts 2-year fall risk in older adults. Taking physician-recommended sleep medications increases the risks for falling in older adults, irrespective of the presence of insomnia symptoms. Future efforts should be directed toward treating insomnia symptoms, and managing and selecting sleep medications effectively to decrease the risk of falling in older adults.
横断面研究表明,失眠症状与晚年跌倒有关。这项纵向研究调查了社区居住的老年人在2年随访期间,失眠症状的严重程度(即多种并存的失眠症状)和睡眠药物对跌倒风险的独立及交互作用。
利用健康与退休研究(2006 - 2014年,N = 6882,年龄中位数 = 74.5岁±6.6岁)的数据,我们计算了参与者报告的失眠症状严重程度(范围 = 0 - 4)(即入睡困难、夜间醒来、过早醒来以及感觉未休息好)。在每次随访时,参与者报告自上次随访以来最近使用的睡眠药物和跌倒情况,并接受平衡和步行速度评估。
在调整已知跌倒风险因素后,基线时更严重的失眠症状负担以及使用医生推荐的睡眠药物可独立预测跌倒。失眠症状对跌倒风险的影响因睡眠药物使用情况而异。对于未使用睡眠药物的人,失眠症状严重程度与跌倒风险呈正的剂量反应关系。使用医生推荐睡眠药物的老年人,无论失眠症状严重程度如何,跌倒风险始终较高。
失眠症状的数量可预测老年人2年的跌倒风险。服用医生推荐的睡眠药物会增加老年人跌倒的风险,无论是否存在失眠症状。未来应致力于治疗失眠症状,并有效管理和选择睡眠药物,以降低老年人跌倒的风险。