小肠和肾近端小管中硫酸盐和磷酸盐的转运：方法与基本特性

Transport of sulfate and phosphate in small intestine and renal proximal tubule: methods and basic properties.

Murer H

Department of Physiology, University of Zurich, Switzerland.

Comp Biochem Physiol A Comp Physiol. 1988;90(4):749-55. doi: 10.1016/0300-9629(88)90694-9.

Abstract

Isolated brush border membrane vesicles, basolateral membrane vesicles, and cultured renal epithelial cells provide good material for studying transport systems. 2. The vesicle systems have been used to study the transport of labeled phosphate, sodium/phosphate cotransport, sodium/sulfate cotransport, basolateral transport of sulfate and basolateral transport of phosphate via anion exchange. 3. Cultured renal cells show sodium/phosphate cotransport and parathyroid dependent inhibition of phosphate transport.

摘要

分离的刷状缘膜囊泡、基底外侧膜囊泡和培养的肾上皮细胞为研究转运系统提供了良好的材料。2. 囊泡系统已被用于研究标记磷酸盐的转运、钠/磷酸盐共转运、钠/硫酸盐共转运、硫酸盐的基底外侧转运以及通过阴离子交换的磷酸盐基底外侧转运。3. 培养的肾细胞显示出钠/磷酸盐共转运以及甲状旁腺对磷酸盐转运的依赖性抑制。