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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Winter C K, Segall H J, Jones A D

Department of Veterinary Pharmacology and Toxicology, University of Calfornia, Davis 95616.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(2):429-33. doi: 10.1016/0742-8413(88)90022-9.

The comparative metabolism of the pyrrolizidine alkaloid (PA) senecionine was studied in vitro in incubations of rat, guinea pig, cow, horse, and sheep hepatic microsomes. 2. Levels of the toxic pyrrolic metabolite 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) were higher from guinea pig incubations (39.9 nmol/mg protein) than from other species (range 0.07 to 7.5 nmol/mg); results disagree with prior studies which used nonspecific techniques and suggest that the guinea pig's resistance to certain PAs may be due to resistance to pyrrole toxicity rather than low pyrrole formation. 3. Minor differences in senecionine N-oxidation and hydrolysis existed between the various species.

在大鼠、豚鼠、牛、马和绵羊肝微粒体的体外孵育实验中，对吡咯里西啶生物碱（PA）千里光碱的代谢情况进行了比较研究。2. 有毒的吡咯代谢物6,7-二氢-7-羟基-1-羟甲基-5H-吡咯里嗪（DHP）在豚鼠孵育实验中的水平（39.9纳摩尔/毫克蛋白质）高于其他物种（范围为0.07至7.5纳摩尔/毫克）；该结果与之前使用非特异性技术的研究结果不一致，表明豚鼠对某些PA的抗性可能是由于对吡咯毒性的抗性，而非低水平的吡咯生成。3. 不同物种之间千里光碱的N-氧化和水解存在细微差异。

Winter C K, Segall H J, Jones A D

Department of Veterinary Pharmacology and Toxicology, University of Calfornia, Davis 95616.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(2):429-33. doi: 10.1016/0742-8413(88)90022-9.

The comparative metabolism of the pyrrolizidine alkaloid (PA) senecionine was studied in vitro in incubations of rat, guinea pig, cow, horse, and sheep hepatic microsomes. 2. Levels of the toxic pyrrolic metabolite 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) were higher from guinea pig incubations (39.9 nmol/mg protein) than from other species (range 0.07 to 7.5 nmol/mg); results disagree with prior studies which used nonspecific techniques and suggest that the guinea pig's resistance to certain PAs may be due to resistance to pyrrole toxicity rather than low pyrrole formation. 3. Minor differences in senecionine N-oxidation and hydrolysis existed between the various species.

在大鼠、豚鼠、牛、马和绵羊肝微粒体的体外孵育实验中，对吡咯里西啶生物碱（PA）千里光碱的代谢情况进行了比较研究。2. 有毒的吡咯代谢物6,7-二氢-7-羟基-1-羟甲基-5H-吡咯里嗪（DHP）在豚鼠孵育实验中的水平（39.9纳摩尔/毫克蛋白质）高于其他物种（范围为0.07至7.5纳摩尔/毫克）；该结果与之前使用非特异性技术的研究结果不一致，表明豚鼠对某些PA的抗性可能是由于对吡咯毒性的抗性，而非低水平的吡咯生成。3. 不同物种之间千里光碱的N-氧化和水解存在细微差异。