酒石酸甲吡酮对豚鼠产热的影响。

Effect of metopirone-ditartrate on thermogenesis in the guinea-pig.

Werner R

Department of Zoophysiology, University of Kiel, FRG.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(2):445-50. doi: 10.1016/0742-8413(88)90025-4.

Abstract

Cortisol is the major corticosteroid in the guinea-pig plasma; cortisone is detected in minor concentrations. 2. An increase in the plasma cortisol level is observed during acute cold exposure. 3. After application of metopirone-ditartrate the standard metabolic rate is depressed significantly at thermoneutrality. 4. In metopirone-treated guinea-pigs the cold-induced increase in heat production is depressed by 47% concomitant with a marked drop in body temperature. 5. It is concluded that the formation of cortisol is essential for regulatory heat production induced by acute cold exposure in the guinea-pig.

摘要

皮质醇是豚鼠血浆中的主要皮质类固醇；仅检测到少量浓度的可的松。2. 在急性冷暴露期间，观察到血浆皮质醇水平升高。3. 应用二酒石酸美替拉酮后，标准代谢率在热中性条件下显著降低。4. 在美替拉酮处理的豚鼠中，冷诱导的产热增加被抑制了47%，同时体温显著下降。5. 得出的结论是，皮质醇的形成对于豚鼠急性冷暴露诱导的调节性产热至关重要。