Inaba T, Tait A, Nakano M, Mahon W A, Kalow W
Department of Pharmacology, University of Toronto, Ontario, Canada.
Drug Metab Dispos. 1988 Jul-Aug;16(4):605-8.
The interindividual variability of diazepam metabolism was studied using human livers. The formation of N-desmethyldiazepam (NDZ) and 3-hydroxydiazepam (temazepam, TMZ), was monitored by gas chromatography. In 10 livers, Km values for NDZ and TMZ formation varied independently from each other, each by a factor of 4, from 100 to 400 microM. This variability is consistent with the presence of at least two different cytochrome P-450 species controlling formation of these metabolites. In the same livers, Vmax for NDZ and TMZ production varied 6-fold and 15-fold, respectively.
利用人肝脏研究了地西泮代谢的个体间变异性。通过气相色谱法监测N-去甲基地西泮（NDZ）和3-羟基地西泮（替马西泮，TMZ）的形成。在10个肝脏中，NDZ和TMZ形成的Km值彼此独立变化，各自变化4倍，范围为100至400微摩尔。这种变异性与至少两种不同的细胞色素P-450物种控制这些代谢物的形成一致。在相同的肝脏中，NDZ和TMZ产生的Vmax分别变化了6倍和15倍。
