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果蝇同源异型基因触角足基因转录本的发育调控可变剪接可产生四种不同的蛋白质。

Developmentally regulated alternative splicing of transcripts from the Drosophila homeotic gene Antennapedia can produce four different proteins.

作者信息

Bermingham J R, Scott M P

机构信息

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.

出版信息

EMBO J. 1988 Oct;7(10):3211-22. doi: 10.1002/j.1460-2075.1988.tb03188.x.

DOI:10.1002/j.1460-2075.1988.tb03188.x
PMID:2903048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC454718/
Abstract

Antennapedia (Antp) is a Drosophila homeotic gene that controls differentiation of the thoracic segments. Antp transcripts are produced from either of two promoters that are independently regulated in temporally and spatially distinct patterns. In addition, Antp transcripts utilize either of two major polyadenylation sites. Antp primary transcripts contain the same protein coding sequences. Alternative RNA splicing at two positions within the primary transcripts produces mRNAs that can encode four slightly different Antp proteins. Different classes of alternatively spliced transcript predominate early and late in Drosophila development, indicating that the Antp gene is regulated by the processing of its transcripts as well as by controlling their transcription. Alternative splicing appears to be independent of which promoter and which polyadenylation site is used.

摘要

触角足基因（Antp）是一种果蝇同源异型基因，它控制胸节的分化。Antp转录本由两个启动子中的任何一个产生，这两个启动子在时间和空间上以不同的模式独立调控。此外，Antp转录本利用两个主要的聚腺苷酸化位点中的任何一个。Antp初级转录本包含相同的蛋白质编码序列。初级转录本内两个位置的可变RNA剪接产生的mRNA可编码四种略有不同的Antp蛋白。不同类型的可变剪接转录本在果蝇发育的早期和晚期占主导地位，这表明Antp基因不仅通过控制转录，还通过转录本的加工来进行调控。可变剪接似乎与使用哪个启动子和哪个聚腺苷酸化位点无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/736ebf3c52f7/emboj00147-0264-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/83da8fdf0c73/emboj00147-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/584f8d5f7558/emboj00147-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/2973cf8ddb8a/emboj00147-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/821638198797/emboj00147-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/4b03e64aca22/emboj00147-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/736ebf3c52f7/emboj00147-0264-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/83da8fdf0c73/emboj00147-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/584f8d5f7558/emboj00147-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/2973cf8ddb8a/emboj00147-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/821638198797/emboj00147-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/4b03e64aca22/emboj00147-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/454718/736ebf3c52f7/emboj00147-0264-a.jpg

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