Shobu R
Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
Gastroenterol Jpn. 1988 Aug;23(4):442-7. doi: 10.1007/BF02779214.
Hybrid adult male dogs were laparotomized before, one week after and one month after 40% hepatectomy. At the same time, an intravenous glucose tolerance test was done (IV-GTT) and pancreatic tissues were removed and examined by PAP staining. The following results were obtained: Carbohydrate metabolism was disturbed and plasma insulin levels were low one week after surgery, but B-cell granulations was at the preoperative level. It seemed that hypersomatostatinemia suppressed insulin release from B cells. Carbohydrate metabolism was restored to normal and the plasma insulin response was increased one month after surgery. Islets of Langerhans cells were hypertrophic and increased after surgery, particularly D cells.
成年杂种雄犬在40%肝切除术前、术后1周和术后1个月接受剖腹手术。同时，进行静脉葡萄糖耐量试验（IV-GTT），切除胰腺组织并用PAP染色检查。获得以下结果：术后1周碳水化合物代谢紊乱，血浆胰岛素水平较低，但B细胞颗粒与术前水平相同。似乎高生长抑素血症抑制了B细胞释放胰岛素。术后1个月碳水化合物代谢恢复正常，血浆胰岛素反应增强。朗格汉斯胰岛细胞术后肥大且增多，尤其是D细胞。
