功能化 hBN 作为靶向光热化疗，以彻底根除癌细胞。
Functionalized hBN as targeted photothermal chemotherapy for complete eradication of cancer cells.
机构信息
Department of Pharmaceutical Sciences, North South University, Plot 15,Block B, Bashundhara R/A, Dhaka-1229, Bangladesh.
Department of Pharmaceutical Sciences, North South University, Plot 15,Block B, Bashundhara R/A, Dhaka-1229, Bangladesh.
出版信息
Int J Pharm. 2017 Dec 20;534(1-2):206-212. doi: 10.1016/j.ijpharm.2017.10.025. Epub 2017 Oct 13.
The development of combined anticancer therapeutic techniques has drawn increased attention for enhanced therapeutic efficacy. In this work, we synthesized Near Infrared (NIR) responsive ICG (I) functionalized hexagonal boron-nitride (hBN) as photothermal therapeutic agent (hBNI) and Doxorubicin (Dox)-conjugated Hyaluronic acid (HA) as tumor targeted chemotherapeutic agent (d-HA-Dox). Using adhesion properties of Dopamine (d), the hBNI has been integrated with d-HA-Dox to make a tumor targeted photothermal chemotherapeutic agent (hBNI/d-HA-Dox). The nanostructure of hBNI/d-HA-Dox has been studied using 1H NMR, FTIR, UV-vis-NIR and AFM images. Our in vitro results have provided evidence that hBNI/d-HA-Dox can efficiently damage targeted cancer cells while healthy cells are less affected suggesting that the targeted hBNI/d-HA-Dox nanoparticles work as a complementary antitumor agent with its synergistic co-therapeutic power.
联合抗癌治疗技术的发展引起了人们对增强治疗效果的极大关注。在这项工作中，我们合成了近红外（NIR）响应吲哚菁绿（ICG）（I）功能化六方氮化硼（hBN）作为光热治疗剂（hBNI）和阿霉素（Dox）偶联透明质酸（HA）作为肿瘤靶向化疗药物（d-HA-Dox）。利用多巴胺（d）的粘附特性，将 hBNI 与 d-HA-Dox 集成在一起，制成肿瘤靶向光热化疗药物（hBNI/d-HA-Dox）。使用 1H NMR、FTIR、UV-vis-NIR 和 AFM 图像研究了 hBNI/d-HA-Dox 的纳米结构。我们的体外结果提供了证据，表明 hBNI/d-HA-Dox 可以有效地损伤靶向癌细胞，而健康细胞受到的影响较小，这表明靶向 hBNI/d-HA-Dox 纳米粒子作为一种互补的抗肿瘤药物，具有协同的联合治疗作用。
Zotero 插件