塞利洛尔与噻吗洛尔及安慰剂的双盲对照两周比较研究

Celiprolol versus timolol and placebo: a two week double-blind comparison.

作者信息

Elman J, Caprioli J, Rosanelli E G, Shields R, Mead A, Sears M, Petillo J

机构信息

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.

出版信息

J Ocul Pharmacol. 1987 Spring;3(1):5-10. doi: 10.1089/jop.1987.3.5.

DOI:10.1089/jop.1987.3.5

PMID:2903202

Abstract

Celiprolol (5%) was compared to timolol (0.5%) and placebo in patients with primary open angle glaucoma or ocular hypertension. A total of 28 patients participated in this double blind study and received treatment for two weeks. Intraocular pressure decreased an average of 4.4 mmHg with celiprolol and 7.1 mmHg with timolol two hours after instillation. This was maintained 12 hours after administration of timolol but not after celiprolol. There was a small but statistically significant decrease in pulse rate 2 hours after administration of timolol (from 72 to 64 beats per minute) which was not observed after celiprolol. Side effects were mild and similar for all 3 groups.

摘要

在原发性开角型青光眼或高眼压症患者中，对塞利洛尔（5%）与噻吗洛尔（0.5%）及安慰剂进行了比较。共有28名患者参与了这项双盲研究，并接受了为期两周的治疗。滴注后两小时，使用塞利洛尔时眼压平均降低4.4 mmHg，使用噻吗洛尔时眼压平均降低7.1 mmHg。噻吗洛尔给药12小时后眼压仍维持降低状态，但塞利洛尔给药后则不然。使用噻吗洛尔两小时后心率有小幅但具有统计学意义的下降（从每分钟72次降至64次），而使用塞利洛尔后未观察到这种情况。三组的副作用均较轻且相似。