基质金属蛋白酶-12在食管鳞状细胞癌中的过表达及其预测意义
The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma.
作者信息
Han Fei, Zhang Suxia, Zhang Long, Hao Qiongyu
机构信息
Division of Radiological Sciences, Washington University School of Medicine in Saint Louis, MO, 63110, USA; Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
出版信息
Pathol Res Pract. 2017 Dec;213(12):1519-1522. doi: 10.1016/j.prp.2017.09.023. Epub 2017 Sep 28.
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells. The high expression of MMP-12 was significantly correlated with tumor grade and stage, nodal metastasis and poor survival of ESCC. Cox multivariate analysis revealed that MMP-12 was an independent prognostic factor in ESCC. Our results suggest that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma.
基质金属蛋白酶（MMP）介导的细胞外基质降解是肿瘤侵袭和转移的主要因素。MMP-12作为金属弹性蛋白酶，其在肿瘤进展中的作用仍存在争议。本研究旨在探讨MMP-12在食管鳞状细胞癌（ESCC）中的作用。我们分析了MMP-12的蛋白表达及其与临床病理参数的关系，并进行了生存分析。与正常上皮细胞相比，MMP-12在肿瘤细胞中高表达。MMP-12的高表达与ESCC的肿瘤分级、分期、淋巴结转移及不良生存显著相关。Cox多因素分析显示，MMP-12是ESCC的独立预后因素。我们的结果表明，MMP-12可能成为食管鳞状细胞癌新型治疗药物开发的潜在靶点。
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