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氟-18-2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描误诊为一例表现为下肢严重水肿的散发性恶性周围神经鞘瘤。

Fluorine-18-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography Masquerading as a Case of Sporadic Malignant Peripheral Nerve Sheath Tumor of Lower Extremity Presenting as Massive Lower Limb Edema.

作者信息

Singh Deepa, Kumar Rajender, Das Ashim, Varma Subhash C, Mittal Bhagwant R

机构信息

Department of Nuclear Medicine, PGIMER, Chandigarh, India.

Department of Histopathology, PGIMER, Chandigarh, India.

出版信息

World J Nucl Med. 2017 Oct-Dec;16(4):324-327. doi: 10.4103/1450-1147.215494.

DOI:10.4103/1450-1147.215494
PMID:29033684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5639452/
Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare neuroectodermal tumors resulting from the malignant transformation of benign plexiform neurofibromas. The sporadic form of these tumors is rare than familial variants (seen in neurofibromatosis Type 1) and making the diagnosis difficult. We are presenting a case of 40--year-old female with the complaint of progressive swelling of lower limb with initial suspicion of lymphedema and underwent lymphoscintigraphy, magnetic resonance imaging, and finally fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scans were done to rule out mitotic etiology and extent of the disease. The patient underwent below-knee amputation, and histopathological examination confirmed the diagnosis of sporadic MPNST.

摘要

恶性外周神经鞘瘤（MPNSTs）是由良性丛状神经纤维瘤恶变形成的罕见神经外胚层肿瘤。这些肿瘤的散发性形式比家族性变体（见于1型神经纤维瘤病）更少见，这使得诊断困难。我们报告一例40岁女性，主诉下肢进行性肿胀，最初怀疑为淋巴水肿，接受了淋巴闪烁显像、磁共振成像检查，最后进行了氟-18-2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描，以排除有丝分裂病因和疾病范围。患者接受了膝下截肢术，组织病理学检查确诊为散发性MPNST。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/68dd6ff909d0/WJNM-16-324-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/6ddb46d845ff/WJNM-16-324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/0c667b7918cc/WJNM-16-324-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/cb1fbf7656d0/WJNM-16-324-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/68dd6ff909d0/WJNM-16-324-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/6ddb46d845ff/WJNM-16-324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/0c667b7918cc/WJNM-16-324-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/cb1fbf7656d0/WJNM-16-324-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0899/5639452/68dd6ff909d0/WJNM-16-324-g004.jpg

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[18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study.[18F]2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG PET）作为1型神经纤维瘤病（NF1）相关恶性外周神经鞘瘤（MPNST）的诊断工具：一项长期临床研究
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