Heldt Manica Lucas A, Cohen Philip R
John A. Burns School of Medicine, University of Hawaii Manoa.
Department of Dermatology, University of California, San Diego.
Cureus. 2017 Aug 11;9(8):e1560. doi: 10.7759/cureus.1560.
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application. The same cutaneous eruption occurred with each subsequent insertion of testosterone pellets. Other cutaneous adverse events associated with testosterone pellet insertion include acne, hirsutism, and male pattern alopecia. Bleeding, bruising, fibrosis, infections, pellet extrusion, scarring, and subcutaneous nodules may also occur at the injection site. In summary, testosterone pellet-induced dermatitis is a rare adverse cutaneous event, which should be added to the list of potential testosterone pellet associated skin side effects.
睾酮替代疗法是用于治疗男性性腺功能减退的一种治疗方法。皮下植入睾酮丸是一种长效、缓释给药系统，可用作雄激素替代疗法。一名接受睾酮丸治疗的77岁男性，在皮下植入睾酮丸后28天内，双侧臀部和大腿出现由红斑性斑块和斑片组成的皮炎。通过外用高效糖皮质激素，皮肤病变迅速消退。随后每次植入睾酮丸时均出现相同的皮肤疹。与植入睾酮丸相关的其他皮肤不良事件包括痤疮、多毛症和男性型脱发。注射部位也可能发生出血、瘀伤、纤维化、感染、丸剂挤出、瘢痕形成和皮下结节。总之，睾酮丸引起的皮炎是一种罕见的皮肤不良事件，应添加到与睾酮丸相关的潜在皮肤副作用列表中。
