Marks J
Girton College, Cambridge, England.
Med Toxicol Adverse Drug Exp. 1988 Jul-Aug;3(4):324-33. doi: 10.1007/BF03259943.
This is a report of a consensus conference on the management of the benzodiazepine-dependent patient. While the focus is on patients who are already dependent, it is better to avoid dependence in therapeutic use by careful patient selection, low dose and short term administration. The management of dependence can normally be undertaken in general practice unless there are complicating factors, e.g. concomitant severe medical, psychiatric or social problems. Inpatient management is also preferable for those abusing drugs in the sociorecreational area. Withdrawal should be achieved by gradual dosage reduction over a period of several weeks. Support from the practitioner, family and friends is important to achieve good results. Since postwithdrawal problems occur, good clinician support is necessary over at least the next year. Despite the risk of dependence, it is stressed that benzodiazepines are valuable therapeutic agents for several psychiatric and physical disorders.
这是一份关于苯二氮䓬类药物依赖患者管理的共识会议报告。虽然重点是已经产生依赖的患者,但通过谨慎选择患者、低剂量和短期给药,在治疗使用中最好避免产生依赖。除非存在复杂因素,如同时伴有严重的医学、精神或社会问题,否则通常可在全科医疗中进行依赖管理。对于在社交娱乐场合滥用药物的患者,住院管理也是较好的选择。应在几周内逐渐减少剂量来实现戒断。从业者、家人和朋友的支持对于取得良好效果很重要。由于戒断后问题会出现,至少在接下来的一年里,良好的临床医生支持是必要的。尽管存在依赖风险,但强调苯二氮䓬类药物对于多种精神和身体疾病是有价值的治疗药物。