Watson T W, Pittman Q J
Faculty of Medicine, Department of Medical Physiology, University of Calgary, Alta., Canada.
Neurosci Lett. 1988 Aug 31;91(2):172-6. doi: 10.1016/0304-3940(88)90763-x.
In the in vitro hippocampal slice somatostatin has been shown to cause a direct hyperpolarization of CA 1 pyramidal neurons by increasing a potassium conductance which is resistant to blockade by tetraethylammonium 4-aminopyridine, or cesium ions. Results reported here demonstrate that this somatostatin-induced hyperpolarization is blocked by 1 mM barium and 5 x 10(-5) M carbachol, with the action of carbachol being reversed by atropine. Barium and carbachol both inactivate the m-current and these results suggest that somatostatin may exert its hyperpolarizing action on CA1 pyramidal cells by activation of the m-current.
在体外海马切片中，已表明生长抑素通过增加一种对四乙铵、4-氨基吡啶或铯离子阻断有抗性的钾电导，直接使CA1锥体神经元超极化。此处报告的结果表明，这种生长抑素诱导的超极化被1 mM钡和5×10⁻⁵ M卡巴胆碱阻断，卡巴胆碱的作用可被阿托品逆转。钡和卡巴胆碱都使m电流失活，这些结果表明生长抑素可能通过激活m电流对CA1锥体细胞发挥其超极化作用。
