a Department of Pharmaceutical Sciences , Guru Nanak Dev University , Amritsar , India.
Nat Prod Res. 2018 Dec;32(23):2861-2864. doi: 10.1080/14786419.2017.1385005. Epub 2017 Oct 16.
has been traditionally used for treatment of abdominal pain, burning sensation and as stomachic. The anti-inflammatory effect of aqueous and methanol extract of this plant has been studied but detailed investigations on anti-inflammatory activity of stem bark are still not available. Therefore, the present study was designed to evaluate the anti-inflammatory activity of methanol extract and its fractions using carrageenan induced paw oedema model. Methanol extract at the dose of 500 mg/kg and its ethyl acetate fraction at 50 mg/kg showed significant reduction in paw oedema in comparison with standard drug. Ethyl acetate fraction was subjected to column chromatography which resulted in isolation of a new flavonoid (GM-01). Anti-inflammatory effect of methanol extract and its fractions can be attributed to the presence of the flavonoid GM-01. Further studies are underway for evaluation of anti-inflammatory effect of GM-01 and identification of active constituents present in ethyl acetate fraction.
一直以来，它都被用于治疗腹痛、灼热感和胃病。该植物的水提物和甲醇提取物具有抗炎作用，但关于其茎皮的抗炎活性的详细研究尚未见报道。因此，本研究旨在评估甲醇提取物及其馏分在角叉菜胶诱导的爪肿胀模型中的抗炎活性。与标准药物相比，在 500mg/kg 的剂量下，甲醇提取物和 50mg/kg 的乙酸乙酯馏分可显著减轻爪肿胀。乙酸乙酯馏分经柱层析分离出一种新的黄酮类化合物（GM-01）。甲醇提取物及其馏分的抗炎作用可能归因于黄酮类 GM-01 的存在。目前正在进行进一步的研究，以评估 GM-01 的抗炎作用，并鉴定乙酸乙酯馏分中存在的活性成分。
