创伤性脑损伤患者血小板分布宽度水平与预后预测
Level of Platelet Distribution Width and Outcome Prediction in Patients with Traumatic Brain Injury.
作者信息
Zhang Biao, Gu Jianjun, Qiu Yizhen, Zhao Jin, Song Yi, Jiang Huojun, Ding Aliang, Chen Xiaoqi, Yu Rongming, Liu Guofang, Hu Aihao
出版信息
Clin Lab. 2017 Oct 1;63(10):1711-1715. doi: 10.7754/Clin.Lab.2017.170520.
BACKGROUND
This study examines the clinical utility of the level of increased platelet distribution width (PDW) as a predictor of outcome in patients with traumatic brain injury.
METHODS
In this retrospective study, 120 patients with traumatic brain injury (TBI) were recruited. Age, gender, PDW, and Glasgow Coma Scale (GCS) scores were measured. These patients were divided into two groups based on their 30-day outcomes. Receiver operating curves (ROCs) were generated to identify predictors of 30-day mortality.
RESULTS
One hundred twenty patients with traumatic brain injury were enrolled in this study, 89 males (74.2%) and 31 females (25.8%) with a median age of 49.5 (19 - 89) years. The in-hospital mortality rate was 10.8% (n = 13). PDW levels in non-surviving patients were higher than in surviving patients. The higher the PDW, the lower the GSC score. The area under the curve (AUC) for PDW levels with regard to predicting 30-day mortality was 0.88 (95% confidence interval (CI), 0.78 to 0.97; p < 0.001). There was correlation between PDW level and GCS score (r = -0.30, 95% confidence interval (CI), - 0.46 to - 0.13; p < 0.001).
CONCLUSIONS
PDW levels were associated with injury severity and mortality in patients with severe TBI.
背景
本研究探讨血小板分布宽度（PDW）升高水平作为创伤性脑损伤患者预后预测指标的临床效用。
方法
在这项回顾性研究中，招募了120例创伤性脑损伤（TBI）患者。测量了年龄、性别、PDW和格拉斯哥昏迷量表（GCS）评分。根据这些患者30天的预后情况将他们分为两组。生成受试者工作特征曲线（ROC）以确定30天死亡率的预测指标。
结果
本研究共纳入120例创伤性脑损伤患者，其中男性89例（74.2%），女性31例（25.8%），中位年龄为49.5岁（19 - 89岁）。住院死亡率为10.8%（n = 13）。未存活患者的PDW水平高于存活患者。PDW越高，GSC评分越低。PDW水平预测30天死亡率的曲线下面积（AUC）为0.88（95%置信区间（CI），0.78至0.97；p < 0.001）。PDW水平与GCS评分之间存在相关性（r = -0.30，95%置信区间（CI），- 0.46至- 0.13；p < 0.001）。
结论
PDW水平与重度TBI患者的损伤严重程度和死亡率相关。
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