Berglund U, Wallentin L, von Schenck H
Department of Internal Medicine, University Hospital, Linköping, Sweden.
Thromb Haemost. 1988 Aug 30;60(1):21-4.
Seventy-three (58 men and 15 women) survivors of myocardial infarction below 45 years of age and 73 healthy matched controls were investigated regarding in vitro platelet aggregability to ADP and collagen, platelet sensitivity to prostacyclin and plasma levels of beta-thromboglobulin, platelet factor 4 and fibrinogen. The patients, studied 3-6 months after the acute event, had a reduced platelet sensitivity to prostacyclin. They did not differ from the controls regarding the other platelet function tests. Females had higher platelet reactivity than men. Smoking, obesity or beta-blocker treatment did not influence platelet function. The patients had higher fibrinogen levels than the controls. Gender did not influence, while smoking and obesity increased plasma fibrinogen. Patients on beta-blockade had lower fibrinogen levels than patients without this therapy. The high fibrinogen level and the low platelet sensitivity to prostacyclin might indicate an increased thrombotic liability in young myocardial infarction patients.
对73名年龄在45岁以下的心肌梗死幸存者（58名男性和15名女性）以及73名匹配的健康对照者进行了研究，检测他们体外血小板对二磷酸腺苷（ADP）和胶原蛋白的聚集性、血小板对前列环素的敏感性以及血浆中β-血小板球蛋白、血小板第4因子和纤维蛋白原的水平。这些患者在急性事件发生3至6个月后接受研究，其血小板对前列环素的敏感性降低。在其他血小板功能测试方面，他们与对照组没有差异。女性的血小板反应性高于男性。吸烟、肥胖或β受体阻滞剂治疗对血小板功能没有影响。患者的纤维蛋白原水平高于对照组。性别不影响纤维蛋白原水平，而吸烟和肥胖会使其升高。接受β受体阻滞剂治疗的患者纤维蛋白原水平低于未接受该治疗的患者。高纤维蛋白原水平和低血小板对前列环素的敏感性可能表明年轻心肌梗死患者的血栓形成倾向增加。
